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The Impact of Obesity and Type 2 Diabetes on Chronic Liver Disease

Younossi, Zobair M. MD, MPH1,2; Henry, Linda PhD2,3

American Journal of Gastroenterology: November 2019 - Volume 114 - Issue 11 - p 1714–1715
doi: 10.14309/ajg.0000000000000433

The growing global epidemic of obesity and type 2 diabetes mellitus (T2DM) has led to the increasing prevalence of nonalcoholic fatty liver disease. In addition, the presence of obesity and T2DM has been shown to increase the likelihood of adverse outcomes in patients with chronic liver disease. In a study by Harris et al., a combination of obesity and T2DM was associated with an increased risk for higher liver stiffness, as measured by transient elastography. It is possible that public health and clinical intervention targeting these components of metabolic syndrome can lead to improved outcomes of subjects with nonalcoholic fatty liver disease and other chronic liver diseases.

1Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA;

2Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA;

3Center for Outcomes Research in Liver Diseases, Washington, District of Columbia, USA.

Correspondence: Zobair M. Younossi, MD, MPH. E-mail:

Received September 02, 2019

Accepted September 09, 2019

Online date: October 9, 2019

© The American College of Gastroenterology 2019. All Rights Reserved.
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