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Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate

A First Prospective Comparison Study

Bar-Gil Shitrit, Ariella MD1; Ben Ya'acov, Ami PhD2; Livovsky, Dan Meir MD2; Cuker, Tzufit BSN1; Farkash, Rivka MPH3; Hoyda, Aviya BSc1; Granot, Tami PhD1; Avni-Biron, Irit MD4; Lahat, Adi MD5; Goldin, Eran MD2; Grisaru-Granovsky, Sorina MD3

American Journal of Gastroenterology: July 2019 - Volume 114 - Issue 7 - p 1172–1175
doi: 10.14309/ajg.0000000000000186
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OBJECTIVES: Despite encouraging data gathered in inflammatory bowel diseases (IBD) patients, Vedolizumabs' (VDZ) safety profile in pregnancy is not established.

DESIGN: Data of 330 consecutive pregnancies with IBD was prospectively collected.

RESULTS: Women with IBD were treated with: VDZ (n = 24), anti-tumor necrosis factors (n = 82) or conventional therapy (n = 224). Gravidity and parity were similar among the 3 groups. The VDZ group was comprised mostly of Crohn's disease patients who were all not naïve to biological treatment. They had significantly higher conception rates during active disease (P < 0.05), with fewer flares during pregnancy.

DISCUSSION: Although further study is needed, VDZ appears of low risk during pregnancy.

1“IBD Mother (MOM)” Unit, Digestive Diseases Institute, Shaare Zedek Medical Center, affiliated with the Medical School, Hebrew University, Jerusalem, Israel;

2Digestive Diseases Institute, Shaare Zedek Medical Center, affiliated with the Medical School, Hebrew University, Jerusalem, Israel;

3Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, affiliated with the Medical School, Hebrew University Jerusalem, Israel;

4Department of Gastroenterology, Rabin Medical Center, Petach Tikva, Israel;

5Gastroenterology Department, Sheba Medical Center, Ramat Gan, Israel.

Correspondence: Ariella Bar-Gil Shitrit. E-mail: ariellash@szmc.org.il.

Received September 05, 2018

Accepted January 25, 2019

© The American College of Gastroenterology 2019. All Rights Reserved.
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