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Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Vuppalanchi, Raj, MD1; Weber, Regina, BS1; Russell, Sarah, MD1; Gawrieh, Samer, MD1; Samala, Niharika, MD1; Slaven, James E., MS2; Harden, Lauren, RD, MBA1; Chalasani, Naga, MD1

American Journal of Gastroenterology: June 2019 - Volume 114 - Issue 6 - p 995–997
doi: 10.14309/ajg.0000000000000116

OBJECTIVES: To investigate the effect of meal intake on liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) in patients with biopsy-proven nonalcoholic fatty liver disease undergoing vibration-controlled transient elastography.

METHODS: LSM and CAP were assessed at baseline and serially for 6 hours after meal intake in 24 patients.

RESULTS: A significant increase in LSM was seen up to the 2-hour time point (26 ± 25%, P = 0.02). The CAP scores changed minimally with a maximal change of 3% (P > 0.1).

CONCLUSIONS: Three hours of fasting is necessary before evaluation with vibration-controlled transient elastography.

1Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA;

2Department of Biostatistics, Indiana University-Purdue University, Indianapolis, Indiana, USA.

Correspondence: Naga Chalasani, MD. E-mail:

Received October 17, 2018

Accepted December 11, 2018

© The American College of Gastroenterology 2019. All Rights Reserved.
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