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Hepatitis B Virus and HIV Coinfection

Fibrosis, Fat, and Future Directions

Kim, Arthur Y., MD1

American Journal of Gastroenterology: May 2019 - Volume 114 - Issue 5 - p 710–712
doi: 10.14309/ajg.0000000000000231

HIV and hepatitis B virus (HBV) share routes of transmission, and coinfection is associated with higher levels of HBV DNA, accelerated fibrosis progression, and increased liver-related events compared with those with HBV alone. The full spectrum of hepatic histology has not been recently addressed, in part because of the decreasing use of liver biopsy in clinical practice. The current study provides a modern “snapshot” of biopsy data from 114 HIV/HBV coinfected individuals, elucidating the degree of liver fibrosis years into the effective antiretroviral era and also revealing that hepatic steatosis was a frequent finding.

1Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Correspondence: Arthur Y. Kim. E-mail:

Received February 25, 2019

Accepted March 04, 2019

© The American College of Gastroenterology 2019. All Rights Reserved.
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