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ACG Clinical Guideline

Ulcerative Colitis in Adults

Rubin, David T., MD, FACG1; Ananthakrishnan, Ashwin N., MD, MPH2; Siegel, Corey A., MD, MS3; Sauer, Bryan G., MD, MSc (Clin Res), FACG (GRADE Methodologist)4; Long, Millie D., MD, MPH, FACG5

American Journal of Gastroenterology: March 2019 - Volume 114 - Issue 3 - p 384–413
doi: 10.14309/ajg.0000000000000152

Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the preferred approach to the management of adults with UC and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. In instances where the evidence was not appropriate for GRADE, but there was consensus of significant clinical merit, “key concept” statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not only, approach to clinical scenarios.

1Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL, USA;

2Division of Gastroenterology, Crohn's and Colitis Center, Massachusetts General Hospital, Boston, MA, USA;

3Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA;

4Department of Medicine, University of Virginia, Charlottesville, VA, USA;

5Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.

Correspondence: Millie D. Long, MD, MPH, FACG. E-mail:; David T. Rubin, MD, FACG. E-mail:

Received June 29, 2018

Accepted January 09, 2019

© The American College of Gastroenterology 2019. All Rights Reserved.
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