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The Unfulfilled Promise of Prokinetics for Functional Dyspepsia/Postprandial Distress Syndrome

Tack, Jan, MD, PhD1; Van den Houte, Karen, MPharm1; Carbone, Florencia, PhD1

American Journal of Gastroenterology: February 2019 - Volume 114 - Issue 2 - p 204–206
doi: 10.14309/ajg.0000000000000072

Abstract: Functional dyspepsia (FD) is subdivided into epigastric pain syndrome and postprandial distress syndrome according to the Rome IV consensus. Based on the assumption that disordered gastric motility is a key pathophysiologic factor in postprandial distress syndrome, prokinetic agents are often proposed as the treatment of choice for this subgroup. Although a meta-analysis suggests that prokinetic agents may be efficacious and safe in FD, there is a lack of widely available agents of proven efficacy. This review analyzes some of the difficulties and challenges in establishing therapeutic efficacy of prokinetic drugs in FD.

1Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium.

Correspondence: Jan Tack, MD, PhD. E-mail:

Received October 18, 2018

Accepted November 08, 2018

© The American College of Gastroenterology 2019. All Rights Reserved.
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