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Comparing the Real-World Effectiveness of Competing Colonoscopy Preparations

Results of a Prospective Trial

Gu, Phillip, MD1,2; Lew, Daniel, MD1,3; Oh, Sun Jung, MD1; Vipani, Aarshi, MD1; Ko, Jeffrey, MD1; Hsu, Kevin, MD1; Mirakhor, Ebrahim, MD1; Pattisapu, Varun, MD1; Bullen, Tia, RN1,3; Fuller, Garth, MS1,4–6; Spiegel, Brennan M.R., MD, MSHS1,3–5,7; Almario, Christopher V., MD, MSHPM1,3–6

American Journal of Gastroenterology: February 2019 - Volume 114 - Issue 2 - p 305–314
doi: 10.14309/ajg.0000000000000057
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OBJECTIVES: National societies provide little guidance regarding which colonoscopy bowel preps are best tolerated and most effective; this reflects a lack of comparative effectiveness studies that directly evaluate the available preps in a “real-world” setting. To address this gap, we conducted a prospective, commercially unfunded comparative effectiveness study of currently available bowel preps and measured their impact on bowel cleansing.

METHODS: We included patients aged ≥18 years, who presented for an outpatient colonoscopy at a large medical center serving more than 70 academic and community-based endoscopists who are free to prescribe the bowel prep of their choice. The primary outcome was bowel cleansing quality as measured by the Boston Bowel Preparation Scale. We performed regression models with random effects on the outcomes to adjust for confounding.

RESULTS: Approximately 4,339 colonoscopies were performed by 75 endoscopists. Magnesium citrate, MiraLAX with Gatorade, MoviPrep, OsmoPrep, Prepopik/Clenpiq, and Suprep all had significantly higher prep tolerability compared with GoLYTELY (all P < 0.05). For bowel cleansing, Suprep (7.28 ± 1.66; P < 0.001), MoviPrep (7.11 ± 1.62; P = 0.004), and MiraLAX with Gatorade (7.09 ± 1.64; P < 0.001) had higher total Boston Bowel Preparation Scale scores compared with GoLYTELY (6.67 ± 1.87); there were no significant differences among the remaining preps. Split-prep dosing was associated with better cleansing; however, men, opioid and tricyclic antidepressent users, and patients with diabetes and cirrhosis had worse cleansing (all P < 0.05).

CONCLUSIONS: In this prospective, real-world comparative effectiveness study of available bowel preps, we found that MiraLAX with Gatorade, MoviPrep, and Suprep were prospectively associated with superior tolerability and bowel cleansing.

1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA;

2Division of Digestive and Liver Diseases, UT Southwestern, Dallas, Texas, USA;

3Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, California, USA;

4Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, California, USA;

5Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, California, USA;

6Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, California, USA;

7Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, California, USA.

Correspondence: Christopher V. Almario, MD, MSHPM. E-mail: Christopher.Almario@csmc.edu.

SUPPLEMENTARY MATERIAL accompanies this paper at http://links.lww.com/AJG/A16 and http://links.lww.com/AJG/A17.

Received March 19, 2018

Accepted November 05, 2018

© The American College of Gastroenterology 2019. All Rights Reserved.
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