EDITORIALTo Screen or Not to Screen Adults 45-49 Years of Age: That is the QuestionAnderson, Joseph C. MD, MHCDS1; Samadder, Jewel N. MD, MSc2Author Information 1Dartmouth College, Hanover, NH, White River Junction VAMC, and UCONN Health Center, Farmington, CT, USA. 2Mayo Clinic, Phoenix, AZ, USA. Correspondence: J.C.A. (email: [email protected]) or N.J.S. (email: [email protected]) Received 22 September 2018; accepted 19 October 2018; Published online 1 November 2018 American Journal of Gastroenterology: December 2018 - Volume 113 - Issue 12 - p 1750-1753 doi: 10.1038/s41395-018-0402-3 Buy Metrics Abstract Should we adopt the recently published American Cancer Society (ACS) recommendations to screen adults at 45 years of age? The main reasons for adopting the recommendation include the increase of colorectal cancer (CRC) in the young, especially late-stage tumors. Screening at 45 years is also supported by predictive modeling, which the ACS employed using updated and improved models as compared to those previously used by the United States Preventive Services Task Force. Reasons against adopting include concerns with the models as well as diversion of scarce screening resources away from high-risk populations. Readers are provided with opposing viewpoints regarding the ACS recommendation. © The American College of Gastroenterology 2018. All Rights Reserved.