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Learning to be More Positive About FIT

Robertson, Douglas J. MD, MPH1,2

American Journal of Gastroenterology: December 2018 - Volume 113 - Issue 12 - p 1757–1759
doi: 10.1038/s41395-018-0400-5

Systematic application of the fecal immunochemical test (FIT) as a screen for colorectal cancer has been shown to meaningfully impact colorectal cancer incidence and mortality. However, there is room for improvement. FIT performance is impacted by a host of patient level factors such as sex and medication use. Meta-analysis has defined those factors most likely to result in a false positive or false negative test. Further work determining how best to gather information on important factors and incorporate them into the FIT result will further enhance the accuracy and outcomes accomplished with this valuable screening test.

1Department of Veterans Affairs Medical Center, White River Junction, VT, USA. 2The Geisel School of Medicine at Dartmouth & The Dartmouth Institute, Hanover, NH, USA.

Correspondence: D.J.R. (email:

Received 10 September 2018; accepted 6 October 2018; Published online 5 November 2018

© The American College of Gastroenterology 2018. All Rights Reserved.
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