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Clinical Narrative: Autoimmune Hepatitis

Schmeltzer, Paul A MD; Russo, Mark W MD, MPH

American Journal of Gastroenterology: July 2018 - Volume 113 - Issue 7 - p 951–958
doi: 10.1038/s41395-018-0058-z

Autoimmune hepatitis (AIH) is an inflammatory liver disease that is characterized by circulating autoantibodies, hypergammaglobulinemia, and a lymphoplasmocytic infiltration with interface hepatitis on liver biopsy. Treatment with corticosteroids and other immunosuppressive agents is effective and early diagnosis can result in near-normal life expectancy. Untreated patients, however, can progress to cirrhosis and liver failure. The clinical presentation is heterogeneous and may pose diagnostic and therapeutic dilemmas. This case-based review will address the diagnosis and management of this disease, in addition to difficult but commonly encountered clinical scenarios.

Division of Hepatology, Carolinas Healthcare, Charlotte, NC, USA.

Correspondence: M.W.R. (email:

Received 9 October 2017; accepted 23 February 2018; Published online 14 May 2018

© The American College of Gastroenterology 2018. All Rights Reserved.
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