1Division of Gastroenterology, Children’s Hospital of Eastern Ontario IBD Centre, Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Eastern Ontario, Ottawa, Canada
2Department of Pediatrics, University of Ottawa, Ottawa, Canada
3School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Canada
4Institute for Clinical Evaluative Sciences, Toronto, Canada
5University of Manitoba IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Canada
6Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
7McGill University Health Centre, Division of Gastroenterology, Montreal, Canada
8Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
9Department of Pediatrics, Dalhousie University, Halifax, Canada
10Department of Pediatrics, University of Manitoba, Winnipeg, Canada
11Mount Sinai Hospital Centre for Inflammatory Bowel Disease, Department of Medicine, University of Toronto, Toronto, Canada
12Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Canada
13Department of Pediatrics, Child and Family Research Institute, University of British Columbia, British Columbia, Canada
14Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
15Department of Medicine, Dalhousie University, Halifax, Canada
16Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
17Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC)
Correspondence: Eric I. Benchimol, MD, PhD, FRCPC, Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Eastern Ontario, Gastroenterology, Hepatology and Nutrition, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. E-mail: [email protected]
SUPPLEMENTARY MATERIAL accompanies this paper at https://links.lww.com/AJG/A521, https://links.lww.com/AJG/A522, https://links.lww.com/AJG/A523
Received 29 August 2016; accepted 16 February 2017
Guarantor of the article: Eric I. Benchimol, MD, PhD, FRCPC.
Specific author contributions: Eric I. Benchimol: study conception and design; analysis and interpretation of data; drafting of manuscript; statistical analysis; obtained funding. Charles N. Bernstein: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Alain Bitton: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Matthew W. Carroll: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Harminder Singh: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Anthony R. Otley: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Maria Vutcovici: analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Wael El-Matary: analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Geoffrey C. Nguyen: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding. Anne M. Griffiths: analysis and interpretation of data; critical revision of the manuscript; obtained funding. David R. Mack: Analysis and interpretation of data; critical revision of the manuscript; obtained funding. Kevan Jacobson: analysis and interpretation of data; critical revision of the manuscript; obtained funding. Nassim Mojaverian: analysis and interpretation of results; statistical analysis; technical support; critical revision of the manuscript for important Divine Tanyingoh: analysis and interpretation of results; statistical analysis; technical support; critical revision of the manuscript for important. Yunsong Cui: analysis and interpretation of results; statistical analysis; technical support; critical revision of the manuscript for important. Zoann Nugent: analysis and interpretation of results; statistical analysis; technical support; critical revision of the manuscript for important. Janie Coulombe: analysis and interpretation of results; statistical analysis; technical support; critical revision of the manuscript for important. Laura E. Targownik: analysis and interpretation of data; critical revision of the manuscript; obtained funding. Jennifer L. Jones: analysis and interpretation of data; critical revision of the manuscript; obtained funding. Desmond Leddin: analysis and interpretation of data; critical revision of the manuscript; obtained funding. Sanjay K. Murthy: analysis and interpretation of data; critical revision of the manuscript; obtained funding. Gilaad G. Kaplan: study conception and design; analysis and interpretation of data; critical revision of the manuscript; statistical analysis; obtained funding.
Financial Support: This research was funded by operating grants from the Crohn’s and Colitis Canada and the Ontario Research Fund: Early Researcher Awards. CanGIEC is funded by the Canadian Institutes of Health Research (CIHR) Foundation Scheme. This study also received financial support from the Canadian Children IBD Network: A Joint Partnership of CIHR and the CH.I.L.D. Foundation. Eric Benchimol and Geoffrey Nguyen were supported by New Investigator Awards from CIHR, Crohn’s and Colitis Canada, and the Canadian Association of Gastroenterology. Charles Bernstein is supported in part by the Bingham Chair in Gastroenterology.
Potential competing interests: The following investigators are also investigators or collaborators in the Canadian Children IBD Network: A Joint Partnership of CIHR and the CH.I.L.D. Foundation, which provided funding for this study: Eric I. Benchimol, Matthew W. Carroll, Anthony R. Otley, Wael El-Matary, Anne M. Griffiths, David R. Mack, Kevan Jacobson, Gilaad G. Kaplan. The following authors served on the Scientific and Medical Advisory Council of Crohn’s and Colitis Canada, which provided funding for this study: Eric I. Benchimol, Charles N. Bernstein, Anthony R. Otley, Gilaad G. Kaplan.
