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Editorial: Moving Away From Focussing on Gastric Pathophysiology in Functional Dyspepsia: New Insights and Therapeutic Implications

Talley, Nicholas J MD, PhD1

American Journal of Gastroenterology: January 2017 - Volume 112 - Issue 1 - p 141–144
doi: 10.1038/ajg.2016.519

Abstract: Functional dyspepsia (FD) is a prevalent syndrome that affects up to one in six Americans, although misdiagnosis as gastroesophageal reflux disease may be common. Early satiety, postprandial fullness, and epigastric pain or burning are the cardinal symptoms. Traditionally, FD has been blamed on gastric dysfunction and much research effort has focussed on unlocking the gastric pathophysiology. New research suggests gastric dysfunction has only a minor role in the pathogenesis in many cases, and the focus has begun to shift to evaluation of duodenal feedback and subtle inflammation including duodenal eosinophilia. These new data and the management implications are reviewed.

1The University of Newcastle, University Drive, Callaghan, New South Wales, Australia

Correspondence: Nicholas J. Talley, MD, PhD, The University of Newcastle, Faculty of Health and Medicine, University Drive, Callaghan, Newcastle, New South Wales 2308, Australia. E-mail:

Received 21 September 2016; accepted 10 October 2016

Guarantor of the article: Nicholas J. Talley, MD, PhD.

Specific author contributions: Nicholas Talley wrote the article.

Financial support: None.

Potential competing interests: None.

© The American College of Gastroenterology 2017. All Rights Reserved.
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