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Diagnosis and Management of Microscopic Colitis

Pardi, Darrell S MD, MS, FACG1

American Journal of Gastroenterology: January 2017 - Volume 112 - Issue 1 - p 78–85
doi: 10.1038/ajg.2016.477
REVIEW: CLINICAL AND SYSTEMATIC REVIEWS
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Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials. This review will describe the clinical features, epidemiology, pathophysiology, diagnostic criteria, and treatment of patients with MC.

1Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA

Correspondence: Darrell S. Pardi, MD, MS, FACG, Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA. E-mail: Pardi.darrell@mayo.edu

Received 01 July 2015; accepted 01 September 2016

Guarantor of the article: Darrell S. Pardi, MD, MS, FACG.

Financial support: None.

Potential competing interests: None.

© The American College of Gastroenterology 2017. All Rights Reserved.
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