Functional GI DisordersEditorial:IBS With Constipation, Functional Constipation, Painful and Non-Painful Constipation:e Pluribus…Plures?Cremonini, Filippo MSc, MD, PhD1; Lembo, Anthony MD2Author Information 1 Southern Nevada VA Healthcare System, Las Vegas, Nevada, USA 2 Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Correspondence: Filippo Cremonini, MSc, MD, PhD, Southern Nevada VA Healthcare System, VA Las Vegas Medical Center, 6900 North Pecos Road, North Las Vegas, Nevada 89086, USA. E-mail: [email protected] Received 18 March 2014; accepted 23 April 2014 American Journal of Gastroenterology: June 2014 - Volume 109 - Issue 6 - p 885-886 doi: 10.1038/ajg.2014.119 Buy Metrics Abstract IBS with constipation (IBS-C) and chronic constipation (CC) can be difficult to distinguish clinically. The Rome III criteria create mutual exclusion between IBS-C and CC, based on the presence of abdominal pain, which is a defining criterion for IBS-C. Previous surveys found that up to 45% of CC patients have abdominal pain and other IBS features. A Spanish general population study proposes a subclassification of patients with CC based on abdominal pain and other features of IBS. As the Rome criteria evolve, these and other observations provide the basis for further efforts in discerning key features of IBS-C and CC. © The American College of Gastroenterology 2014. All Rights Reserved.