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Effect ofHelicobacter pyloriEradication on Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasm

Bae, Suh Eun MD1; Jung, Hwoon-Yong MD, PhD, AGAF1; Kang, June MD2; Park, Young Soo MD, PhD2; Baek, Seunghee PhD3; Jung, Ji-Hoon MD1; Choi, Ji Young MD1; Kim, Mi-Young MD1; Ahn, Ji Yong MD1; Choi, Kwi-Sook MD1; Kim, Do Hoon MD1; Lee, Jeong Hoon MD1; Choi, Kee Don MD, PhD1; Song, Ho June MD, PhD1; Lee, Gin Hyug MD, PhD1; Kim, Jin-Ho MD, PhD1

American Journal of Gastroenterology: January 2014 - Volume 109 - Issue 1 - p 60–67
doi: 10.1038/ajg.2013.404
ORIGINAL CONTRIBUTIONS: STOMACH
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OBJECTIVES: Although many epidemiologic studies have shown thatHelicobacter pylori(H. pylori) eradication has prophylactic effects on gastric cancer, their results are less clear in high-risk populations. We conducted this study to examine whetherH. pylorieradication would affect the occurrence of metachronous gastric cancer after endoscopic resection in patients with early gastric cancer.

METHODS: We retrospectively analyzed 2,089 adults who underwent endoscopic resection of gastric low-grade neoplasia, high-grade neoplasia, or differentiated invasive neoplasia from 2004 to 2008 at Asan Medical Center. Of these, a total of 1,007 patients with early gastric cancer were enrolled in this study. We evaluated the demographic data, the pathology, and the incidence of metachronous recurrence by dividing them into three groups: those without activeH. pyloriinfection (Hp negative group,n=340), those who successfully underwentH. pylorieradication (eradicated group,n=485), and those who failed or did not undergoH. pylorieradication (noneradicated group,n=182).

RESULTS: Metachronous recurrence was diagnosed in 75 patients, including 17 in the Hp, 34 in the eradicated, and 24 in the noneradicated groups. Median time to metachronous recurrence was 18 months (range, 7–75 months). The incidence of metachronous gastric cancer was 10.9 cases per 1,000 person-years in the Hp negative group, 14.7 cases per 1,000 person-years in the eradicated group, and 29.7 cases per 1,000 person-years in the noneradicated group. The hazard ratios in the noneradicated group compared with the Hp negative and eradicated groups were 2.5 (P<0.01) and 1.9 (P=0.02), respectively.H. pylorieradication reduced metachronous recurrence of gastric neoplasm, which was also shown in the secondary analysis of 1,487 patients with low-grade neoplasia and early gastric cancer.

CONCLUSIONS: SuccessfulH. pylorieradication may reduce the occurrence of metachronous gastric cancer after endoscopic resection in patients with early gastric cancer.

1 Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, South Korea

2 Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, South Korea

3 Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, South Korea

Correspondence: Hwoon-Yong Jung, MD, PhD, AGAF, Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, 388-1 Pungnap-dong Songpa-gu, 138-736 Seoul, South Korea. E-mail: hyjung@amc.seoul.kr

Received 14 May 2013; accepted 1 October 2013

published online 17 December 2013

© The American College of Gastroenterology 2014. All Rights Reserved.
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