Abstract: Clinical and epidemiological findings implicate genetic predisposition and the effects of elevated steroids in pregnancy in the pathogenesis of intrahepatic cholestasis of pregnancy. To date, a number of studies have identified polymorphisms encoding biliary canalicular transporters, including those encoded byABCB4andABCB11, which are associated with intrahepatic cholestasis of pregnancy. Questions remain regarding divergent findings between populations and the relative contributions of these polymorphisms. In a large study of Western European women with intrahepatic cholestasis of pregnancy, Dixonet al.(this issue) provide further insights into the genetics of this cholestatic syndrome, which contribute to ongoing evaluation of cholestasis generally.
1 Centre for Liver Research/NIHR Biomedical Research Unit, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
2 Liver Unit, Queen Elizabeth Hospital, Birmingham, UK
Correspondence: Gideon M Hirschfield, Centre for Liver Research/NIHR Biomedical Research Unit, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK. E-mail: firstname.lastname@example.org
Received 25 October 2013; accepted 13 November 2013