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Surgery in a Population-Based Cohort of Crohn's Disease From Olmsted County, Minnesota (1970–2004)

Peyrin-Biroulet, Laurent MD, PhD1, 2; Harmsen, Scott W MS3; Tremaine, William J MD1; Zinsmeister, Alan R PhD3; Sandborn, William J MD1, 4; Loftus, Edward V Jr MD1

American Journal of Gastroenterology: November 2012 - Volume 107 - Issue 11 - p 1693–1701
doi: 10.1038/ajg.2012.298
ORIGINAL CONTRIBUTIONS: INFLAMMATORY BOWEL DISEASE
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OBJECTIVES: We sought to estimate the need for surgery in an American population-based cohort of Crohn's disease.

METHODS: The medical records of 310 incident cases of Crohn's disease from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed through March 2009. Cumulative incidence was estimated using the Kaplan–Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression and expressed as hazards ratios (HRs) with 95% confidence intervals.

RESULTS: Median follow-up per patient was 12 years. One hundred and fifty-two patients underwent at least 1 major abdominal surgery, 65 had at least 2 surgeries, and 32 had at least 3 surgeries. The cumulative probability of major abdominal surgery was 38, 48, and 58% at 5, 10, and 20 years after diagnosis, respectively. Baseline factors significantly associated with time to major abdominal surgery were: ileocolonic (HR, 3.3), small bowel (HR, 3.4), and upper gastrointestinal (HR, 4.0) extent, relative to colonic alone; current cigarette smoking (HR, 1.7), male gender (HR, 1.6), penetrating disease behavior (HR, 2.7), and early corticosteroid use (HR=1.6). Major abdominal surgery rates remained stable, with 5-year cumulative probabilities in 1970–1974 and 2000–2004 of 37.5 and 35.1%, respectively.

CONCLUSIONS: The cumulative probability of major abdominal surgery in this population-based cohort of Crohn's disease approached 60% after 20 years of disease, and many patients required second or third surgeries. Non-colonic disease extent, current smoking, male gender, penetrating disease behavior, and early steroid use were significantly associated with major abdominal surgery.

1 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA

2 Department of Hepato-Gastroenterology, University Hospital of Nancy, Henri Poincare University, Vandoeuvre-les-Nancy, France

3 Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA

4 Division of Gastroenterology, University of California San Diego, La Jolla, California, USA

Correspondence: Edward V. Loftus, Jr, MD, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street, S.W., Rochester, Minnesota 55905, USA. E-mail: loftus.edward@mayo.edu

SUPPLEMENTARY MATERIAL accompanies this paper at http://links.lww.com/AJG/A545, http://links.lww.com/AJG/A546, http://links.lww.com/AJG/A547, http://links.lww.com/AJG/A548, http://links.lww.com/AJG/A549, http://links.lww.com/AJG/A550, http://links.lww.com/AJG/A553, http://links.lww.com/AJG/A555

Received 12 February 2012; accepted 26 July 2012

Presented in part at the 111th Annual Meeting of the American Gastroenterological Association, New Orleans, Louisiana, May 1-6, 2010 (Peyrin-Biroulet L, et al. Cumulative incidence of and risk factors for major abdominal surgery in a population-based cohort of Crohn's disease. Gastroenterology 2010;138(5 Suppl 1): S1184).

published online 4 September 2012

© The American College of Gastroenterology 2012. All Rights Reserved.
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