Functional GI DisordersEffects of Gut-Directed Hypnotherapy on IBS in Different Clinical Settings—Results From Two Randomized, Controlled TrialsLindfors, Perjohan MD1, 2, 3; Unge, Peter MD, PhD4, 5; Arvidsson, Patrik PhD2; Nyhlin, Henry MD, PhD6; Björnsson, Einar MD, PhD1; Abrahamsson, Hasse MD, PhD1; Simrén, Magnus MD, PhD1Author Information 1 Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden 2 Department of Internal Medicine, Gävle County Hospital, Gävle, Sweden 3 Department of Gastroenterology, Sabbatsbergs Hospital, Stockholm, Sweden 4 Örebro University Hospital, Örebro, Sweden 5 Novartis Pharma AG, Basel, Switzerland 6 Department of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden Correspondence: Magnus Simrén, MD, PhD, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden. E-mail: email@example.com Received 23 February 2011; accepted 26 August 2011 published online 4 October 2011 American Journal of Gastroenterology: February 2012 - Volume 107 - Issue 2 - p 276-285 doi: 10.1038/ajg.2011.340 Buy Metrics Abstract OBJECTIVES: Gut-directed hypnotherapy has been found to be effective in irritable bowel syndrome (IBS). However, randomized, controlled studies are rare and few have been performed outside highly specialized research centers. The objective of this study was to study the effect of gut-directed hypnotherapy in IBS in different clinical settings outside the traditional research units. METHODS: The study population included IBS patients refractory to standard management. In study 1, patients were randomized to receive gut-directed hypnotherapy (12 sessions, 1 h/week) in psychology private practices or supportive therapy, whereas patients were randomized to receive gut-directed hypnotherapy in a small county hospital or to serve as waiting list controls in study 2. Gastrointestinal symptom severity and quality of life were evaluated at baseline, at 3 months follow-up and after 1 year. RESULTS: We randomized 138 IBS patients refractory to standard management, 90 in study 1 and 48 in study 2. In both the studies, IBS-related symptoms were improved at 3 months in the gut-directed hypnotherapy groups (P<0.05), but not in the control groups (ns). In study 1, a significantly greater improvement of IBS-related symptom severity could be detected in the gut-directed hypnotherapy group than in the control group (P<0.05), and a trend in the same direction was seen in study 2 (P=0.17). The results seen at 3 months were sustained up to 1 year. CONCLUSIONS: Gut-directed hypnotherapy is an effective treatment alternative for patients with refractory IBS, but the effectiveness is lower when the therapy is given outside the highly specialized research centers. © The American College of Gastroenterology 2012. All Rights Reserved.