Globus is a common functional symptom without a clearly accepted etiology. Upper esophageal sphincter (UES) hypertension and gastroesophageal reflux have been proposed but not confirmed. Kwiateket al.report a detailed study in globus patients using high-resolution manometry (HRM). The study showed greater respiratory augmentation of UES pressure compared with control groups among two-thirds of globus patients. Further prospective studies are needed to confirm these findings and to establish whether they are of etiologic significance.
1Digestive Diseases Centre, University Hospitals of Leicester, Leicester, UK.
Correspondence: John de Caestecker, MD, FRCP, Department of Gastroenterology, Digestive Diseases Centre, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. E-mail: firstname.lastname@example.org
Am J Gastroenterol 2009; 104:299-301; doi:10.1038/ajg.2008.152; published online 20 January 2009
Received 17 October 2008; accepted 27 October 2008