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Colonic Perforation as a Complication of Collagenous Colitis in a Series of 12 Patients

Allende, Daniela S., M.D.1; Taylor, Shari L., M.D.2; Bronner, Mary P., M.D.1

American Journal of Gastroenterology: October 2008 - Volume 103 - Issue 10 - p 2598–2604
ORIGINAL CONTRIBUTIONS: PATHOLOGY
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OBJECTIVES The rare complication of colonic perforation in collagenous colitis following colonoscopy or barium enema is reported in this series of 12 patients.

METHODS Patients with collagenous colitis complicated by perforation were collected from the authors' consultation files between 1992 and 2007. Colectomy and biopsy specimens were reviewed and the corresponding clinical data were analyzed.

RESULTS The patients ranged in age from 44 to 80 yr, with a female-to-male ratio of 11:1. Perforation occurred during colonoscopy in 2 patients, within 0–5 days following colonoscopy in 8 patients, and during barium enema in 2 patients. The most notable colonoscopic findings were bleeding linear ulcers of the right colon in 9 patients, several of which developed under direct visualization during endoscopy. The perforation culminated in right hemicolectomy in 11 patients. Linear fissuring ulcers were identified in the resections of 8 patients along with features of perforation, including pneumatosis in 4 patients and barium extravasation within the muscularis propria in 2 patients.

CONCLUSIONS This is the largest published series to date, and the first to uncover several novel clinicopathologic features of perforation in collagenous colitis, including the right colonic predilection (corresponding to disease severity), the association with not only colonoscopy, but also barium enema, the occurrence of recognizable perforation actually developing during the procedure, and a more detailed information on the marked histologic severity of these patients' collagenous colitis. An awareness of this rare but potentially fatal complication of collagenous colitis may facilitate its diagnosis and management.

1Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio; 2Caris Diagnostics, Irving, Texas

Reprint requests and correspondence: Mary P. Bronner, M.D., Department of Anatomic Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195.

CONFLICT OF INTEREST

Guarantor of the article: Mary P. Bronner, M.D.

Specific author contributions: Each author contributed to the original design of the paper, the data collection and analysis, and the writing and critical revisions of the final manuscript.

Financial support: None.

Potential competing interests: None.

Received November 15, 2007; accepted April 14, 2008.

© The American College of Gastroenterology 2008. All Rights Reserved.
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