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Acute Pancreatitis in Patients on Chronic Peritoneal Dialysis

An Increased Risk?

Quraishi, Essam R., M.D; Goel, Sachin, M.D; Gupta, Mini, M.D; Catanzaro, Andrew, M.D; Zasuwa, Gary, B.S; Divine, George, Ph.D

American Journal of Gastroenterology: October 2005 - Volume 100 - Issue 10 - p 2288–2293

OBJECTIVES The primary aim of this study is to determine if patients with end-stage renal disease (ESRD) on peritoneal dialysis (PD) have a higher risk of developing acute pancreatitis (AP) than patients on hemodialysis (HD). The secondary aim is to compare the outcomes of AP between the two groups.

METHOD This is a retrospective case-control study. The study groups consisted of all patients initiated on HD and PD between January 1, 1998 and August 1, 2003. AP was identified using ICD-9 codes. Statistical analysis was carried out using Poisson regression, Kaplan-Meier curve, log-rank test, and Cox regression.

RESULTS One thousand two hundred and thirty-three and 160 eligible patients were identified in the HD and PD groups, respectively. Twenty-eight patients had AP. Eight patients were excluded as they had identifiable etiologies for AP. Of the remaining 20 patients with AP, 14 were in the HD group and 6 were in the PD group (p = 0.009). Incidence of AP was 18.4 per 1,000 person-years in the PD group and 6.5 per 1,000 person-years in the HD group (p = 0.033). Kaplan-Meier curves showed a significant difference in AP-free survival between the two groups (log-rank p = 0.026). Using time-dependent analysis, the hazard ratio for AP in PD patients after adjustment for age and sex was 3.94 (p = 0.006). There was no observed difference in length of hospital stay and ICU stay. All cases of AP were interstitial. There were no complications or deaths related to AP.

CONCLUSION PD is a risk factor for AP. There is no statistical difference in AP-related mortality and morbidity between HD and PD.

Reprint requests and correspondence: Sachin Goel, M.D., Digestive Care Associates, 1700 Hospital South Drive, Suite #502, Anstell, GA 30106.

Received October 9, 2004; accepted May 4, 2005.

© The American College of Gastroenterology 2005. All Rights Reserved.
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