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Persistence of Abnormal Gastrointestinal Motility After Operation for Hirschsprung's Disease

Miele, Erasmo, MD1; Tozzi, Arturo, MD1; Staiano, Annamaria, MD1,3; Toraldo, Caterina, MD1; Esposito, Ciro, MD2; Clouse, Ray E, MD, FACG3

American Journal of Gastroenterology: May 2000 - Volume 95 - Issue 5 - p 1226–1230
doi: 10.1111/j.1572-0241.2000.02014.x

OBJECTIVE: Recent studies in patients with Hirschsprung's disease (HD) suggest that morphological abnormalities of the intramural intestinal plexuses are not restricted to the colon. In this report, symptoms and objective tests of gastrointestinal (GI) motor dysfunction were determined long after operative treatment to see whether evidence of a more widespread and relevant motility disturbance could be detected.

METHODS: Twenty-one children were available for study an average of 6.6 yr after surgery for HD. All of these patients underwent evaluation of bowel frequency per week, total GI transit time (TGTT), and a scintigraphic gastric emptying test using solid food; anorectal manometry and segmental colonic transit times were performed in a subset of patients. Results were compared with findings in appropriately matched controls.

RESULTS: Frequency of defecation per week in patients with HD after surgery was not different from that in control children, but TGTT was significantly longer (p < 0.01). Percentage retention of gastric isotope at 60 min exceeded the normal range in 12 of 21 (57.1%) patients, and colonic transit was abnormal in all six children studied. Symptoms persisted in two-thirds of patients postoperatively, and transit abnormalities were more common in the symptomatic subset (p = 0.026).

CONCLUSIONS: Our data show that, in a subset of patients with HD, GI motor dysfunction persists long after surgical correction. The heterogeny of basic defects responsible for HD could provide the substrate for these motor abnormalities that, in turn, seem at least partially responsible for continuation of the symptomatic state.

1Department of Pediatrics, University “Federico II,” Naples, Italy

2Division of Pediatric Surgery, University “Federico II,” Naples, Italy

3Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA

Reprint requests and correspondence: Annamaria Staiano, MD, Department of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Received 18 December 1998; accepted 18 November 1999

© The American College of Gastroenterology 2000. All Rights Reserved.
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