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Evidence of Impaired Gallbladder Function in Patients With Liver Cirrhosis by Quantitative Radionuclide Cholescintigraphy

Kao, Chia-Hung, MD1; Hsieh, Jih-Fang, MD2; Tsai, Shih-Chuan, MD3; Ho, Yung-Jen, MD4; Chen, Shy-Den, MD5

American Journal of Gastroenterology: May 2000 - Volume 95 - Issue 5 - p 1301–1304
doi: 10.1111/j.1572-0241.2000.02029.x

OBJECTIVE: The aim of this study was to understand gallbladder function in liver cirrhosis.

METHODS: Gallbladder function was measured in 45 patients with liver cirrhosis by Tc-99m–labeled imino-diacetic acid analog cholescintigraphy. Gallbladder function was represented by the filling fraction and the ejection fraction (EF). The patients were divided into three groups, based on cirrhotic severity, using the modified Child's classification: A = good, B = fair, and C = poor. Fifteen normal control subjects were selected for comparison.

RESULTS: There were no significant differences in filling fraction among all of the study groups. Normal controls had significantly higher 60-min EF values than did liver cirrhosis patients. Among the liver cirrhosis patients, class A patients had the highest EF values, and class C patients had the lowest EF values.

CONCLUSIONS: We found that liver cirrhosis may significantly impair the gallbladder emptying, based on the evidence of quantitative Tc-99m–labeled imino-diacetic acid analog cholescintigraphy findings.

1Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

2Department of Nuclear Medicine, Chi-Mei Foundation Hospital, Tainan, Taiwan

3Department of Nuclear Medicine, Show-Chwan Memorial Hospital, Changhua, Taiwan

4Department of Radiology, Jen-Ai Hospital, Taichung, Taiwan

5Department of Internal Medicine, Provincial Fong Yuan Hospital, Taichung, Taiwan

Reprint requests and correspondence: Chia-Hung Kao, MD, Department of Nuclear Medicine, Taichung Veterans General Hospital, 160 Taichung Harbor Road, Section 3, Taichung 40705, Taiwan.

Received 19 May 1999; accepted 28 December 1999

© The American College of Gastroenterology 2000. All Rights Reserved.
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