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The Impact of Peptic Ulcer Disease and Infection WithHelicobacter pyloriOn Life Expectancy

Inadomi, John M, MD1, 2, *; Sonnenberg, Amnon, MD, MSc1, 2

American Journal of Gastroenterology: August 1998 - Volume 93 - Issue 8 - p 1286–1290
doi: 10.1111/j.1572-0241.1998.00410.x
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Objective: Knowledge about the influence ofH. pylori-related disease on life expectancy might affect physician behavior in dealing with such disease. The aim of this study was to assess how life expectancy is influenced byH. pyloriinfection and peptic ulcer disease.

Methods: The declining exponential approximation of life expectancy was used to model the effects ofH. pyloriand various peptic ulcer disease conditions on life expectancy. Deaths from peptic ulcer and gastric cancer were determined from the Vital Statistics of the United States.H. pyloriprevalence rates were derived from the existing literature.

Results: Cure of active peptic ulcer increases life expectancy by 2.3 yr in persons aged 40–44 yr and 121 days in persons aged 70–74 yr. More substantial impact occurs in complicated ulcer, with increases in life expectancy ranging between 26.1 and 6.3 yr. Primary prevention ofH. pyloricould increase life expectancy by 190 days in those aged 40–44 yr and 26 days in 70–74-yr-old subjects.

Conclusion: The benefit of ulcer cure orH. pyloriprevention diminishes as age advances. Cure of ulcers in young patients or in those who have sustained complications results in an appreciable increase in life expectancy. Successful primary prevention ofH. pyloriin selected populations could substantially increase life expectancy.

1 Division of Gastroenterology, VA Medical Center, Albuquerque, New Mexico USA

2 Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico USA

* Division of Gastroenterology 501-111F, Veterans Affairs Medical Center, 2100 Ridgecrest Drive S.E., Albuquerque, NM 87108

Received February 09, 1998; accepted May 11, 1998.

© The American College of Gastroenterology 1998. All Rights Reserved.
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