Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Antilactoferrin Antibodies in Autoimmune Liver Diseases

Ohana, Masaya, MD1, *; Okazaki, Kazuichi, MD2; Hajiro, Kiyoshi, MD1; Uchida, Kazushige, MD2

American Journal of Gastroenterology: August 1998 - Volume 93 - Issue 8 - p 1334–1339
doi: 10.1111/j.1572-0241.1998.444_n.x
Original Contributions: PDF Only

Objective: Lactoferrin, an immunoregulatory protein in mucosal secretions, is one of the target antigens to perinuclear antineutrophil cytoplasmic antibodies (P-ANCAs). Circulating lactoferrin is cleared in the liver, but little is known about the implication of lactoferrin in hepatic inflammation. To evaluate the implication of immunological response to lactoferrin, we examined antilactoferrin antibodies in autoimmune liver diseases.

Methods: Fourteen patients with primary biliary cirrhosis (PBC), 14 with autoimmune hepatitis (AIH), five with autoimmune cholangitis (AIC), six with chronic hepatitis C, and five with chronic hepatitis B were studied. We evaluated autoantibodies to lactoferrin in the sera of the patients by the Western Immunoblotting method.

Results: Sera of five of the 14 patients (35.7%) with PBC, four of the 14 patients (28.6%) with AIH, and five of the five patients (100%) with AIC contained autoantibodies to human lactoferrin, but none with hepatitis B or C had them. The higher prevalence of serum antibodies to human lactoferrin was shown to be higher in patients with AIC than with hepatitis B (p< 0.01), hepatitis C (p< 0.01), PBC (p< 0.05), and AIH (p< 0.05).

Conclusion: Lactoferrin located in bile ducts and liver cells is one of the candidates of target antigens in autoimmune liver diseases, especially in AIC.

1 Department of Gastroenterology, Tenri Hospital, Kyoto, Japan

2 Department of Endoscopy and Gastroenterology, Kyoto University, Kyoto, Japan

* Department of Endoscopy and Gastroenterology, Fuculty of Medicine, Kyoto University, Sakyo, Kyoto, 606-8507 Japan

Received September 30, 1997; accepted April 24, 1998.

© The American College of Gastroenterology 1998. All Rights Reserved.
You currently do not have access to this article

To access this article:

Note: If your society membership provides full-access, you may need to login on your society website