As long-acting HIV prevention options gain momentum, the spotlight shifts to equitable access Filip, Iulia Filip, Iulia Less AIDS. 39(12):N17-N19, October 01, 2025. Favorite PDF Permissions Buy
Doxycycline to prevent bacterial sexually transmitted infections: a promising intervention Rubenstein, Emma; Molina, Jean-Michel Rubenstein, Emma; Molina, Jean-Michel Less AIDS. 39(12):1677-1687, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary Bacterial STIs are rising globally, affecting MSM, TGW, and cisgender women, especially pregnant women. Behavioral changes haven't curbed this trend, and vaccines aren't available, so doxycycline postexposure prophylaxis (doxyPEP) is being explored. Clinical trials show doxyPEP effectively reduces Chlamydia and syphilis in MSM and TGW, but not in cisgender women, likely due to adherence issues. Concerns remain about antibiotic resistance, particularly in Neisseria gonorrheae, and effects on the microbiome. While doxyPEP lowers STI rates, challenges like acceptability and access persist. Guidelines vary internationally, highlighting the need for consistent STI prevention strategies. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy
Neutralizing antibodies and restriction factors cooperatively exert selective pressure on the HIV-1 envelope glycoprotein Marceau, Thomas; Migraine, Julie; Moreau, Alain; More Marceau, Thomas; Migraine, Julie; Moreau, Alain; Arrouche, Youness; Andriantsoanirina, Valérie; Verrier, Bernard; Mammano, Fabrizio; Meyer, Laurence; Braibant, Martine Less AIDS. 39(12):1699-1708, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary This study examined how HIV-1 envelope glycoproteins (Env) change in their vulnerability to certain immune restriction factors and antibodies as infection progresses. Researchers compared Env variants from five individuals during early and chronic phases of HIV infection. They found that early-phase variants were more sensitive to restriction factors IFITM3, SERINC5, and MARCH8 than chronic-phase variants. Adding IFITM3 and SERINC5 to viral particles increased their sensitivity to neutralizing antibodies. This suggests that these factors might enhance antibody effectiveness, offering insights for potential therapeutic strategies. More research is needed to understand these interactions and their implications for HIV treatment. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy SDC
Risks for sudden cardiac and undetermined cause of death among people with HIV in the REPRIEVE primary cardiovascular prevention trial deFilippi, Christopher; Awwad, Aya; Bloomfield, Gerald S.; More deFilippi, Christopher; Awwad, Aya; Bloomfield, Gerald S.; Weir, Isabelle R.; Ribaudo, Heather; Zanni, Markella V.; Fichtenbaum, Carl J.; Malvestutto, Carlos D.; Aberg, Judith A.; Diggs, Marissa R.; Chu, Sarah M.; Paradis, Kayla; MacArthur, Roger D.; Pilotto, Jose; Marks, Kristen; Van Dam, Cornelius; Wilkin, Aimee; Currier, Judith S.; Zhao, Sophia; Wiviott, Stephen D.; Lu, Michael T.; Douglas, Pamela S.; Grinspoon, Steve Less AIDS. 39(12):1709-1720, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary This study examined sudden cardiac death (SCD) and undetermined deaths (UDD) among people with HIV (PWH) using data from the REPRIEVE trial. The trial involved 7769 PWH with low-to-moderate cardiovascular risk, assessing factors like ECG abnormalities and substance abuse. Over 5.6 years, 25 participants experienced SCD and 53 had UDD. SCD was linked to cardiovascular risk factors and ECG signs of heart issues, while UDD was associated with substance abuse and detectable HIV viral load. These findings highlight different risk profiles for SCD and UDD, suggesting tailored prevention strategies for PWH. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy SDC
Virological success despite archived INSTI drug resistance mutations on INSTI-based antiretroviral regimens Merad, Yanis; Mariaggi, Alice-Andrée; Karmochkine, Marina; More Merad, Yanis; Mariaggi, Alice-Andrée; Karmochkine, Marina; Slama, Laurence; Brière, Etienne; Launay, Odile; Viard, Jean-Paul; Charre, Caroline Less AIDS. 39(12):1749-1754, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary This study looked at people with HIV who are virologically suppressed and on integrase strand transfer inhibitor (INSTI) regimens, to see if archived drug resistance mutations (DRMs) affect their treatment. Researchers found 30 INSTI DRMs in 26 individuals, mostly in defective proviruses, and noted that these mutations did not lead to virologic failure over a median follow-up of 202 days. The study suggests that archived DRMs in defective proviruses do not compromise virological control, but further research is needed to understand their impact and guide treatment decisions, especially when considering regimen changes. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy
Posttraumatic stress disorder and its associations with morbidity and mortality among veterans with HIV Vyas, Kartavya J.; Marconi, Vincent C.; Agan, Brian K.; More Vyas, Kartavya J.; Marconi, Vincent C.; Agan, Brian K.; Sullivan, Patrick S.; Guest, Jodie L. Less AIDS. 39(12):1760-1772, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary This study examined how PTSD affects health outcomes in veterans with HIV receiving care in the VA. Among 3,206 veterans on antiretroviral therapy, PTSD was linked to higher risks of several conditions, including AIDS, chronic kidney disease, COPD, multimorbidity, cardiovascular disease, and arthritis, with hazard ratios ranging from 1.11 to 1.95. These associations were strongest in the first decade after HIV diagnosis. PTSD did not increase risks for asthma, cancer, cerebrovascular disease, diabetes, liver disease, or overall mortality. The findings suggest that trauma-informed care and PTSD screening could improve health management for veterans with HIV. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy SDC
Are we ending the HIV epidemic among persons who inject drugs?: key findings from 19 US cities Baugher, Amy R.; Wejnert, Cyprian; Kanny, Dafna; More Baugher, Amy R.; Wejnert, Cyprian; Kanny, Dafna; Broz, Dita; Feelemyer, Jonathan; Hershow, Rebecca B.; Burnett, Janet; Chapin-Bardales, Johanna; Haynes, Maya; Finlayson, Teresa; Prejean, Joseph; for the NHBS Study Group* Less AIDS. 39(12):1813-1819, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Plain Language Summary The National HIV Behavioral Surveillance (NHBS) tracks HIV-related behaviors among people who inject drugs (PWID) to assess progress toward Ending the HIV Epidemic (EHE) goals. Data from 2018 and 2022 show that in 2022, 45% of PWID were tested for HIV, 45% of PWID with HIV were linked to care within 1 month of diagnosis, and 79% were currently taking antiretroviral therapy (ART). Only 1% of HIV-negative PWID used preexposure prophylaxis (PrEP), and approximately half of all PWID received syringes from a syringe services program (SSP). PrEP and SSP use among PWID have not changed since 2018. These findings indicate that current national HIV strategies are insufficient for PWID, highlighting the need for tailored interventions and improved access to testing, treatment, and prevention services. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Buy
The role of ECG in risk prediction for sudden cardiac and unexpected death in people with HIV Dawood, Halima Dawood, Halima Less AIDS. 39(12):1820-1821, October 01, 2025. Favorite PDF Permissions Buy
Multisector global collaboration to advance the inclusion of pregnant and lactating people in HIV prevention research Schaefer, Robin; Lievense, Breanne; Day, Suzanne; More Schaefer, Robin; Lievense, Breanne; Day, Suzanne; Donaldson, Logan; Bekker, Linda-Gail; Chigome, Audrey; Kumwenda, Grace; Noguchi, Lisa; Osakwe, Chukwunomso; Miller, Veronica; Lyerly, Anne Drapkin; Chatani-Gada, Manju Less AIDS. 39(12):1835-1838, October 01, 2025. Favorite PDF Permissions Open
Under-reporting of HIV and AIDS as an underlying cause of death in South Africa Groenewald, Pam; Glass, Tracy; Kallis, Natasha; More Groenewald, Pam; Glass, Tracy; Kallis, Natasha; Holmgren, Chantelle; Nojilana, B.; Maqungo, Monique; Cheyip, Mireille; Morof, Diane; Nannan, Nadine; Bradshaw, Debbie Less AIDS. 39(12):1839-1841, October 01, 2025. Abstract Abstract Plain Language Summary Plain Language Summary Favorite PDF Permissions Go to Full Text of this Article Plain Language Summary In South Africa, there is significant under-reporting of HIV-related and AIDS-related deaths, with only 27.9% of these deaths documented in medical records being reported in official cause of death data. This discrepancy is influenced by past AIDS denialism, confidentiality concerns, and stigma, leading to a reluctance to record HIV as a cause on death certificates. This under-reporting can result in inaccurate statistics, potentially impacting the allocation of resources needed to address the HIV epidemic effectively. Text is machine generated and may contain inaccuracies. View Plain Language Summary safety and compliance information Open
Acute hepatitis B infections among PWH treated with 2-drug regimen: can we trust the vaccination status? Todesco, Eve; Valantin, Marc-Antoine; Akhavan, Sepideh; More Todesco, Eve; Valantin, Marc-Antoine; Akhavan, Sepideh; Rouget, Rémi; Wirden, Marc; Passe-Coutrin, Priscila; Saliba, Sanaa; Cocherie, Théophile; Tubiana, Roland; Faycal, Antoine; Stitou, Hind; Vergely, Olivier; Chevaliez, Stéphane; Amiot, Xavier; Agher, Rachid; Palich, Romain; Calvez, Vincent; Pourcher, Valérie; Marcelin, Anne-Geneviève; Seang, Sophie Less AIDS. 39(12):1845-1847, October 01, 2025. Favorite PDF Permissions Buy
