Secondary Logo

Journal Logo

Correspondence

SARS-CoV-2 infection in a highly experienced person living with HIV

Di Giambenedetto, Simonaa,b; Del Giacomo, Paolaa; Ciccullo, Arturoa,b; Porfidia, Angeloc; De Matteis, Giuseppec; Cianci, Rossellac; De Vito, Francescoc; Dusina, Alexa,b; Borghetti, Albertoa; Tumbarello, Marioa,b

Author Information
doi: 10.1097/QAD.0000000000002572
  • Free

Since the first cases reported in December 2019 in Wuhan (Hubei, China) [1], coronavirus disease 2019 (COVID-19) has spread all over the world, until reaching the state of pandemic, as recognized by the WHO [2]. Patients infected by the SARS-CoV-2, the etiological agent of COVID-19, showed symptoms of fever, cough and dyspnea, lymphopenia, and interstitial pneumonia in radiological examinations [3,4]. About 20% of cases develop severe diseases, with life-threatening complications such as respiratory failure, shock, and multiple organ dysfunction [5]. Given the correlation with lymphopenia, it was thought that people living with HIV could have an increased risk of contracting COVID-19 and, moreover, of manifesting a severe form of the disease. A joint statement from European AIDS Clinical Society (EACS) and British HIV Association (BHIVA) [6] clarified that, with current data, there is no clear evidence of a higher COVID-19 infection rate or different disease course in people with HIV than in HIV-negative people. To the best of our knowledge, only one case was reported of HIV and COVID-19 coinfection in a newly diagnosed 61-year-old man in China [7].

We hereby report the case of a 75-year-old male patient, with a history of 23 years since HIV diagnosis. The patient did not have an AIDS-defining event in his clinical history, his nadir CD4+ cell count was 159 cell/μl, whereas his last determination prior to hospital admission was 709 cell/μl with an undetectable HIV-RNA. He had a resolved hepatitis B virus (HBV) infection and suffered from high blood pressure and was in treatment with perindopril.

On 21 March 2020, he was hospitalized following a 7-days history of high fever, diarrhea, and cough. At the emergency department, molecular (real-time polymerase chain reaction) assay of nasopharyngeal swab for SARS-CoV-2 was performed, resulting positive. Blood exams showed a C-reactive protein value of 45 mg/l (reference value <5), a lactate dehydrogenase determination of 221 U/l (reference value <250), a d-dimer of 2232 ng/ml (reference value <500) and a leukocyte count of 6340/μl, with a lymphocites’ count of 1380/μl. Chest radiographs showed bilateral signs of interstitial pneumonia with ground-glass opacity in the anterior segment of the upper right lobe. Antiretroviral therapy was hence modified, discontinuing the single tablet regimen (STR) of rilpivirine/emtricitabine/tenofovir alafenamide and starting a STR with darunavir/cobicistat/emtricitabine/tenofovir alafenamide. Hydroxycloroquine was also started for the treatment of COVID-19 along with antibiotic therapy with azithromycin. In the days immediately following, clinical conditions worsened, with persistent fever and worsening dyspnea, requiring a progressive increase in oxygen supplementation up to a FiO2 of 0.6. On 28 March, sarilumab was administered, at the dosage of 200 mg intravenously; a second dose of 200 mg of sarilumab was administered on 31 March. Following the lenghtening of the QT interval and the finding of marked bradycardia with atrioventricular block, on 1 April, both hydroxycloroquine and azithromycin were discontinued. Following two distinct episodes of hemoptysis, a computed tomography scan of the lungs was performed on 3 April, showing bilateral consolidations and ‘ground-glass’ opacities, in the absence of signs of bleeding or signs of pulmonary embolism.

Starting on 4 April, we observed a progressive improvement in clinical conditions, with the resolution of fever and improvement of respiratory parameters and gas exchange. Oxygen supplementation was rapidly discontinued. Two consecutive molecular essays of naso-pharyngeal swabs on 6 and 7 April tested negative, and the patient was discharged on 9 April with good clinical conditions.

Our work describes one of the first reported cases of COVID-19 in a person living with HIV. In our patient, antiretroviral therapy was switched to a protease inhibitor (PI)-based strategy, based on the evidence that some PIs have ‘in-vitro’ activity against SARS-CoV-2 [8], although clinical trials failed to show significant advantages of PIs in severe forms of COVID-19 [9]. The patient failed to improve after initial therapy with hydroxycloroquine and azithromycin was started; as a matter of fact, the association of these two drugs, both of whom are potentially cardiotoxic, caused the observed conduction disorder. The improvement, meanwhile, was observed following administration of sarilumab, a humanized antihuman IL-6 receptor antibody of the IgG1 subclass, currently investigated as a potential therapeutic agent against COVID-19. In our case, sarilumbab was administered at a reduced dosage given the history of HBV infection; no hepatitis flares were observed during hospitalization. It is also worth mentioning that, during hospitalization, the patient was administered low molecular weight heparin at prophylactic dose, following initial reports on the potential benefit of anticoagulant therapy in SARS-CoV-2 infections [10]. The described patient was able to achieve complete clinical recovery, despite having presented a very severe clinical course. Although people living with HIV do not show an increased risk of contracting COVID-19, the clinical course of the disease could be more insidious in this group of patients.

Acknowledgements

The current study was performed as part of our routine work.

Transparency declarations: A.B. has received nonfinancial support from Bristol-Myers Squibb and ViiV Healthcare, and personal fees from Gilead Sciences and Janssen. S.D.G. was a paid consultant or member of advisory boards for Gilead, ViiV Healthcare, Janssen-Cilag, Merck Sharp & Dohme and Bristol-Myers Squibb. All other authors: none to declare.

Conflicts of interest

There are no conflicts of interest.

References

1. Fauci AS, Lane HC, Redfield RR. COVID-19 – navigating the uncharted. N Engl J Med 2020; 382:1268–1269.
2. World Health Organization (WHO). WHO Director-General's opening remarks at the media briefing on COVID-19-11 March 2020. Available at: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19-11-march-2020.
3. Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multicenter study in Wenzhou City, Zhejiang, China. J Infect 2020; 80:388–393.
4. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395:1054–1062. [Published correction appears in Lancet. 2020 Mar 28;395(10229):1038].
5. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020.
6. EACS & BHIVA Statement on risk of COVID-19 for people living with HIV (PLWH). https://www.eacsociety.org/home/covid-19-and-hiv.html. [Accessed on 22 March 2020].
7. Zhu F, Cao Y, Xu S, Zhou M. Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan City, China. J Med Virol 2020.
8. Choy KT, Yin-Lam Wong A, Kaewpreedee P, Sia SF, Chen D, Hui KPY, et al. Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res 2020; 178:104786.
9. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med 2020; [Epub ahead of print].
10. Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 2020; 18:1094–1099.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.