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EPIDEMIOLOGY AND SOCIAL

Increasing voluntary medical male circumcision uptake among adult men in Tanzania

Wambura, Mwita; Mahler, Hally; Grund, Jonathan M.; Larke, Natasha; Mshana, Gerry; Kuringe, Evodius; Plotkin, Marya; Lija, Gissenge; Makokha, Maende; Terris-Prestholt, Fern; Hayes, Richard J.; Changalucha, John; Weiss, Helen A. The VMMC-Tanzania Study Group

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doi: 10.1097/QAD.0000000000001440
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Abstract

Introduction

From 2005 to 2007, three randomized controlled clinical trials in Sub-Saharan Africa (SSA) demonstrated that male circumcision reduces the risk of female-to-male HIV transmission by about 60% [1–3]. In March 2007, the WHO and the Joint United Nations Programme on HIV/AIDS (UNAIDS) recommended that voluntary medical male circumcision (VMMC) should be considered an important intervention for HIV prevention in settings with high HIV and low circumcision prevalence [4]. Mathematical models have estimated that VMMC scale-up across SSA could prevent up to 6 million new HIV infections and 3 million deaths by 2025 [5]. VMMC has been rolled out in 14 African countries starting in 2009, and WHO estimates that 11.7 million men have been circumcised as of December 2015 [6].

Tanzania has an adult HIV prevalence of 5.1% [7]. HIV prevalence varies by region, from 1.5% (Manyara Region) to 14.8% (Njombe region). Overall prevalence of male circumcision in Tanzania was 71.9% in 2011–2012 [7], but cultural and religious practices contribute to wide variation of circumcision prevalence. Several regions (including Dar es Salaam, Pwani, Lindi and Mtwara) had close to universal prevalence, whereas 12 traditionally noncircumcising regions (including Njombe and Tabora) had lower circumcision prevalence, and constituted the Ministry of Health, Community Development, Gender, Elderly, and Children (MOHCDGEC) priority regions for VMMC [7]. The national VMMC programme was launched by the MOHCDGEC following a situational analysis from 2007–2008 that reported high acceptability for VMMC among men and women in both traditionally circumcising and noncircumcising communities [8,9]. The MOHCDGEC developed a VMMC Country Operational Plan targeting 2.2 million men aged 10–34 years with circumcision between 2014 and 2017 in the priority regions [10]. As of September 2016, 1.8 million VMMCs had been performed in Tanzania [11].

Although the national strategy prioritized 10–34 year olds, modeling suggests that the most immediate reduction to HIV incidence may be achieved by circumcising men aged 20–34 years because of higher HIV incidence in this age group [12–14]. To achieve the maximum number of HIV infections averted (3% of new infections) between 2011 and 2015, VMMC should reach sexually active men [5,14]. However, in Tanzania, the majority of clients are younger men; for example, 76% of VMMC clients in 2014 were under 20 years of age [15,16]. Studies in Kenya, Zambia, and Tanzania have described strategies to increase VMMC demand among men aged 20 years or above [17–19] but these strategies did not explicitly explore the relationship between a comprehensive demand-creation approach and uptake of services by older men. In addition, these studies did not explicitly focus on outreach delivery strategy. Outreach delivery strategy is used when targeting a large volume of VMMC clients [15]. Thus, strategies are needed to increase the number and proportion of male clients aged 20–34 years [15].

We conducted a cluster randomized trial (CRT) to assess whether a targeted demand-creation approach and enhanced service delivery model increased the proportion of VMMC clients aged 20–34 years compared with a standard VMMC delivery model, in two regions of Tanzania.

Methods

Study design

The design was a CRT conducted in 20 clusters in traditionally noncircumcising and rural areas in Njombe and Tabora regions, Tanzania (Fig. 1). This design was chosen because the intervention involved cluster-level demand-creation messages and facility-level provision of VMMC. At the time of selection (December 2013), the coverage of VMMC was 41% in Njombe and 50% in Tabora [10]. The trial was conducted at outreach sites where VMMC services had either never been previously provided or had not offered VMMC through outreach in the previous 6 months before study enrolment. These sites were designated as ‘outreach’ sites, where VMMC services were provided for a limited period in an outreach campaign format, often in areas that are rural and hard to reach. The outreach sites were government health facilities (hospitals, health centres, or dispensaries), where MOHCDGEC-employed service providers delivered VMMC services for a period of 1–4 weeks. Outreach sites operated in an area until saturation was reached, that is less than 30 clients a day were seen, at which time, the site was closed and moved to another location. Outreach sites were supplied by a fixed site from which goods and healthcare providers were transported [20]. During these short-term VMMC campaigns, both ‘parent’ and ‘spin-off’ VMMC sites were used. The parent VMMC site was the initial VMMC outreach site established in a catchment area. If saturation was reached, providers opened a spin-off site several kilometres away. The spin-off site stayed open for a minimum of 1 week after start of campaigns and remained open as long as there were at least 10 VMMC clients per day. For the CRT, a cluster included a parent site and related spin-off sites, and was defined as the geographical area of at least 7 km around the parent and all spin-off sites, with a buffer zone of at least 6 km between the boundaries of clusters. No VMMC-related services or demand-creation activities were undertaken in the buffer zones.

Fig. 1
Fig. 1:
Map of Tanzania showing the VMMC study regions and clusters. VMMC, voluntary medical male circumcision.

Ethical approval was obtained from the London School of Hygiene and Tropical Medicine Research Ethics Committee; the Tanzanian Medical Research Coordinating Committee, and the Centers for Disease Control and Prevention (CDC) Institutional Review Board. The study was also overseen by a data monitoring and safety committee. The study is registered at ClinicalTrials.gov, number NCT02376348. All participants provided written informed consent in Swahili before study enrolment. The trial was conducted and reported in accordance with the CONsolidated Standards of Reporting Trials (CONSORT) guidelines for CRTs [21].

Participants

A list of eligible parent sites in Tabora and Njombe regions was compiled. Sites were eligible if they were an outreach VMMC health facility, had not previously provided VMMC services or had not provided VMMC services in the previous 6 months, and were located at least 20 km from other potential parent sites to allow at least 7 km catchment area around the parent and all spin-off sites.

Participants were informed about the study and were recruited following the provision of standard group education session. Eligible participants were men who had voluntarily come to a parent or spin-off site for VMMC, aged at least 10 years, were uncircumcised and who provided voluntary written informed consent to participate in the study. Clients aged less than 18 years provided written informed assent and their parent or guardian provided written informed consent. Eligible clients who consented to be part of the study had nonidentifying information from their individual client record entered into a study database.

Randomization and masking

In total, 20 clusters were recruited, 10 from each region. The allocation sequence was computer-generated with a 1 : 1 allocation ratio within region. The allocation was unmasked to the field teams delivering the intervention and control strategies and to field staff collecting outcome data. Study participants were masked to study arm.

Procedures

Formative research was conducted in Nzega district of Tabora and Njombe district of Njombe region in February and March 2014. Formative research used in-depth interviews, participatory group discussions, and discrete choice experiments (DCEs). In-depth interviews and participatory group discussions were used to identify barriers and facilitators to uptake of VMMC among men aged 20–34 years, whereas DCEs assessed the intervention components that could potentially increase VMMC uptake among 20–34 year olds. These findings informed specific components of the intervention [22,23]. The intervention applied information, motivation, and behaviour theory to findings from the formative study [24]. Clusters randomized to the intervention arm received the following components in addition to the control arm activities: enhanced demand-creation messages, including information on non-HIV benefits; involvement of recently circumcised men from the community as auxiliary peer promoters (APPs; community and peer promotion); separate waiting and group education areas for men aged at least 20 years (facility setup); engagement of female partners in community-based demand creation and education for female partners about wound healing and postcircumcision abstinence (Table 1). Clusters in the control arm received the standard demand creation and facility arrangement for outreach VMMC campaigns in Tanzania.

Table 1
Table 1:
Components of the voluntary medical male circumcision strategy in the control and intervention arms.

Demand creation activities were conducted by 2–4 male and female peer promoters in the control clusters while the intervention clusters had 6–8 promoters (2–4 peer promoters and 4 APPs). They worked with community leaders, displayed banners, and distributed about 2000 flyers and brochures in each cluster. A vehicle with a megaphone communicating specific VMMC-related messages (including locations and operating hours of VMMC) traversed the intervention communities. The demand-creation team also held shows (playing music, traditional dances) and wore T-shirts with specific messages about the VMMC campaign. A mobile information booth was established in communities surrounding each outreach site to provide education and counselling to female partners of the adult men. Education on benefits of VMMC, wound care and healing, and resumption of sexual activity was provided. The booths were managed by peer promoters and health facility staff.

The communities surrounding parent sites in both arms received demand-creation activities for 2 weeks before the outreach campaigns started, and the parent sites conducted VMMCs for 26–34 days. Spin-off sites were exposed to demand-creation activities for approximately 1 week before the launch of services.

All clients recruited into the study provided separate informed consent for VMMC surgery and study participation. The VMMC service provided by the MOHCDGEC, which is based on the WHO-recommended minimum package [25], includes the offer of an HIV test, and an individual VMMC client record is completed for every client, recording key demographic and clinical data, including age, referral source, medical conditions precluding VMMC, previous surgery/surgical complications, history of bleeding problems, allergies to medications, and HIV status. Under standard MOHCDGEC procedures, clients who tested HIV positive received additional counselling and surgery if deemed healthy to undergo VMMC by the clinician and if the client still wanted the procedure postcounselling. Clients testing positive were also referred to HIV care and treatment clinics. Individuals with any contraindications to VMMC were referred, and encouraged to return for VMMC, if appropriate.

For this study, selected fields from the VMMC program-based client record were entered into a separate study database at the site. Each participant was identified by a unique study identification number. No identifying information from the client record was entered into either database. For data quality purposes, the data set generated from the study data management system was compared with the programme database. Any discrepancies were resolved at the site using the source data. Costing data for the intervention were collected and are reported elsewhere [26].

VMMC-related adverse events were recorded and reported following national protocol and WHO guidelines [10,27]. All individuals experiencing adverse events were clinically managed until the event was resolved.

Outcomes

The primary outcome was the proportion of VMMC clients aged 20–34 years. Secondary outcomes were the proportion of clients aged at least 20 years, mean number of clients per cluster aged 20–34 years, and mean number of clients per cluster of all ages. Secondary analyses included analyses stratified by region.

Statistical analysis

The sample size estimates assumed data collection over a month in each of the 20 clusters. Based on 2014 campaign data, we assumed a harmonic mean of 214 clients per month in each control cluster (SD = 140), of whom 20% would be aged 20–34 years. We further assumed that the intervention would increase the number of clients of all ages by 25% (214 per cluster per month in the control arm vs. 268 in the intervention arm). This sample size provides 85% power to detect a difference in the proportion of VMMC clients aged 20–34 years of 20% in the control arm vs. 30% in the intervention arm, assuming a coefficient of variation (k) = 0.35. The sample size also provides over 90% power to detect an increase in the mean number of clients aged 20–34 years seen in the data collection period from 43 (20% of all clients) to 80 (30% of all clients).

Cluster-level summary methods were used to assess the impact of the intervention per analysis plan. The primary outcome was the unadjusted prevalence ratio (PR), estimated as the ratio of the geometric mean proportion of clients aged 20–34 years in the intervention vs. control clusters. The 95% confidence intervals (CI) for the PRs were estimated using a stratified t-test, with variance estimated from the residual mean square from an analysis of variance of community log prevalence on stratum (region) and study arm. For continuous outcomes, analogous cluster-level methods were used, with linear regression to estimate the mean difference by arm, with a 95% CI [28].

Results

A total of 10 485 men sought VMMC services at the 20 sites between 3 November 2014 and 7 March 2015. Of these, 10 219 (97.5%) were enrolled in the study. The primary reason for nonenrollment was being unwilling to provide informed consent (Fig. 2). Of those enrolled, 10 117 (99.0%) were included in the analysis of the primary outcomes (6191 and 3926 men in the intervention and control arms, respectively).

Fig. 2
Fig. 2:
Flow diagram showing the flow of participants through each stage of the VMMC trial in Tanzania in 2015. VMMC, voluntary medical male circumcision.aThe mean number per cluster and range of cluster sizes is not shown because this is one of the secondary outcomes of the trial.

The proportion of clients aged 20–34 years was greater in the intervention than control arm, although this was not statistically significant (17.7 vs. 13.0%; PR = 1.36; 95% CI: 0.93–1.98; P = 0.11; Table 2). Similarly, the intervention was associated with the following secondary outcomes: a greater number of clients aged 20–34 years (overall mean difference in number of clients per cluster = 97; 95% CI:40–154; P = 0.002), a greater proportion of clients aged at least 20 years (25.5 vs. 16.0%; PR = 1·60; 95% CI:1.09–2.34; P = 0.02), and a greater number of clients of any age (overall mean difference in number of clients per cluster = 227, 95% CI:33–420; P = 0.03).

Table 2
Table 2:
Proportion and number of circumcised clients in different age groups, by arm and region.

The intervention effect varied significantly by region (P value for effect modification = 0.006; Fig. 3 and Table 2). In Njombe, there was little evidence of a difference in the proportion of men aged 20–34 years in the intervention and control arms (11.3 vs. 14.7%; PR = 0.77, 95% CI: 0.37–1.61; P = 0.44), whereas in Tabora, there was strong evidence of a difference (27.5 vs. 11.5%; PR = 2.39, 95% CI: 1.66–3.43; P < 0.001). Similarly, there was strong evidence of a difference in the mean number of clients aged 20–34 years per cluster in intervention vs. control facilities in Tabora (mean difference = 182; 95% CI 44–320; P = 0.02) and little evidence of a difference in Njombe (mean difference = 12; 95% CI:-14–38; P = 0.32). In contrast, there was strong evidence of a greater overall number of clients seen in the intervention arm than the control arm in Njombe (mean difference = 154, 95% CI 12–297; P = 0.04), but weak evidence of a difference in Tabora (mean difference = 299, 95% CI −102 to 699; P = 0.12).

Fig. 3
Fig. 3:
Proportion of VMMC clients aged 20–34 years in each cluster, by arm and region. VMMC, voluntary medical male circumcision.

As some components of the intervention (communication strategies targeting adult men, education and counseling to female partners of VMMC clients, and VMMC promotion by recently circumcised peers) took place before participants attended the clinics, there were differences in characteristics of intervention and control participants reflecting the intervention (Table 3). For example, clients in the intervention arm were older [median age 15 years, interquartile range (IQR): 12–21 years] than in the control arm (median 13 years, IQR: 11–17 years; Wilcoxon rank sum P < 0.001). Men in the intervention arm were more likely than those in the control arm to be married or cohabiting (22 vs. 8%; P < 0.001). Likely because of older age, the proportion of men testing HIV positive was higher among participants in the intervention arm than the control arm (1.6 vs. 0.8%; P = 0.001) among participants with unknown HIV serostatus. The proportion who agreed to HIV testing was very high in both arms across all age groups (95–100%). Overall, 79.8% of men in the intervention arm, and 82% of men in the control arm returned for at least one postoperative visit (P = 0.48 adjusted for clustering).

Table 3
Table 3:
Characteristics of enrolled voluntary medical male circumcision clients, by arm and region.

Discussion

The proportion of VMMC clients aged 20–34 years was slightly greater in the intervention than control arm overall and there was strong evidence of a difference in Tabora but not Njombe region. The regional differences in the effect of the intervention are likely to be because of different phases of VMMC scale-up between the two regions. The programmatic VMMC implementation started in 2009 in Njombe but in 2011 in Tabora [15]. By the midpoint of study implementation, Njombe region was nearing 80% VMMC coverage [29,30], whereas Tabora region was still at a lower level of coverage. The regional VMMC targets for Njombe and Tabora regions for the period of 2014–2017 were 74 333 and 212 751, respectively [10]. Of these, 45 408 (61% of the target) in Njombe region and 22 861 (11%) men in Tabora region were circumcised in 2014 alone [11]. Therefore, Tabora region still had a large number of uncircumcised men unlike Njombe region. The intervention appeared more effective in areas with low coverage than areas with high VMMC coverage, suggesting that understanding the coverage of VMMC will be extremely important to policy makers and programme planners in designing similar interventions.

The study contributes to the growing evidence on effective demand-creation strategies for VMMC [17,18]. The increase in the number of men of all ages attending VMMC in the intervention arm reflects that many messages in the intervention strategy were attractive to younger as well as older men, and incorporating these elements should be of benefit to general VMMC campaigns. To our knowledge, only three randomized controlled clinical trials in SSA have assessed the effect of a targeted intervention on VMMC uptake among men aged at least 18 years: an economic incentive trial in Kenya [17] and Tanzania [31], and a CRT in Zambia [18]. There are notable differences between these studies and our study. The Zambian study was conducted in urban areas using static/fixed sites delivery model whereas our study was conducted in rural areas using VMMC outreach delivery model. In the Zambian study, VMMC promotion was nested in risk-reduction interventions and reported a VMMC uptake of 40 and 27% in the intervention and control arms, respectively. In the Kenyan and Tanzanian studies, the intervention (economic compensation conditional on undergoing circumcision) happened in the community settings and VMMC at fixed sites. Similar to our study, the Kenyan study showed modest increase in the uptake of VMMC among adult men, ranging from 1.9 to 9% compared with 1.6% reported in the control arm, whereas the Tanzania study increased VMMC among adult men by 47 and 8% in the intervention and control groups, respectively; however, the difference was not statistically significant.

The strength of our trial was the use of formative research to identify optimal communication strategies to overcome barriers to uptake of VMMC among men aged 20–34 years. Such barriers included perceptions of low risk for HIV infection among older men, myths regarding loss of sexual prowess postcircumcision, as well as service-delivery side barriers, including complaints on inconvenient VMMC service hours. Our formative research indicated that older men considered themselves at low HIV risk, and feared that their decision to seek VMMC might be perceived as infidelity to their partners. This led us to incorporate non-HIV benefits of VMMC in addition to HIV and other STIs related-prevention benefits in demand-creation activities targeting older and married men and their female partners. We also used DCEs to assess user preferences for VMMC, which clearly established the desirability of separation of waiting and education areas for younger and older men, use of APPs to address local myths as well as female partner counselling. Additional measures to improve privacy, including using curtains and screens in the operation theatres, were important in intervention facilities, especially given the high-volume nature of VMMC campaigns.

Our formative work also highlighted the need for an expanded role for women in VMMC communication strategies [23]. This study used mobile information booths to provide counselling and education services to female partners of VMMC clients. The booths were managed by peer promoters and health facility staff and addressed the women's questions on VMMC and were also used to coach women on how to encourage male partners who were undecided or reluctant to seek circumcision. Several studies have shown that women influence their partners’ decision to be circumcised [23,32,33]. Providing correct information to women empowers them to play this role and may be an effective way of reaching married adult men.

The study used a dynamic, high-volume outreach model of VMMC campaign in both arms in which parent and spin-off sites are used to increase coverage of VMMC. This is the standard VMMC delivery model in the study regions [15]. This may mean that these findings are not generalizable to static/fixed sites. However, the model described is the standard for service delivery in these regions: of all VMMC clients circumcised in Njombe and Tabora regions during the study period, only 3.6% were circumcised in static sites [11]. Although this design may have increased the uptake of VMMC in both arms, we are unaware of any reason why this design may have increased uptake differentially between the arms. Another limitation is that standard radio messages for VMMC promotion were broadcast in the study regions (intervention, controls, and buffer zone areas) because it was not feasible to prohibit airing the messages in the buffer zone.

Conclusion

Our trial showed that a targeted demand-creation strategy and an improved layout of outreach facilities increased the uptake of VMMC in men aged 20–34 years and among men of all age groups in areas with lower coverage of VMMC. This intervention should be considered as an additional strategy that can contribute towards reaching the fastest reduction in HIV incidence possible in VMMC scale-up.

Acknowledgements

Tanzania VMMC Study Group; Augustino Hellar, MMed (Jhpiego, Dar es Salaam, Tanzania), Naomi Bock, MD (Centers for Disease Control and Prevention, Atlanta, Georgia, USA), Sergio Torres Rueda, MSc (Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK).

The study was funded by Centers for Disease Control and Prevention, Atlanta, Georgia, USA (Grant No: GH000513). H.A.W. and R.J.H. were funded by the UK Medical Research Council and DFID (Grant Grant No G0700837). We are also grateful to our participants, data collection team, VMMC providers, and health authorities for their dedication to the study.

The funder of the study participated in the study design, data interpretation, and writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.

This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention under the terms of the Cooperative Agreement Number GH000513. The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the official position of the funding agencies.

M.W., H.M., J.M.G., N.L., M.P., H.A.W., R.J.H., G.L., and J.C. contributed to the study design. M.W., H.M., M.M., J.M.G., and M.P. oversaw implementation of the intervention and control strategies. G.M., F.T-P. conducted the formative research. E.K. and M.M. managed the data collection. M.W., H.A.W., and N.L. did the data analysis. M.W. and H.A.W. wrote the first draft of the manuscript. All authors contributed in the interpretation of the results and critical revision of the manuscript for important intellectual content.

Tanzania VMMC study group: Naomi Bock and Sergio TorresRueda contributed to the study design. Augustino Hellar oversaw the implementation of the intervention and control strategies.

Conflicts of interest

There are no conflicts of interest.

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Keywords:

adult men; Africa; HIV; voluntary medical male circumcision

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