In May 2009, the Obama administration unveiled a 6-year, $63 billion global health strategy . The initiative provides $51 billion toward the reauthorization of the President's Emergency Plan for AIDS Relief (PEPFAR) and $12 billion for other global health priorities including interventions that focus on maternal and child health (MCH). The emphasis on MCH is based on an innovative proposal by Colleen Denny and Ezekiel Emanuel  (a healthcare advisor to President Obama) known as the Mother and Child Campaign. This initiative would focus on MCH diseases including: ‘diarrheal diseases, respiratory infections, tuberculosis (TB), malaria, vaccine-preventable diseases, neonatal conditions, and obstetric and maternal health problems’ .
The architects of the Mother and Child Campaign have proposed funding MCH at the expense of future funding increases for PEPFAR . The authors claim that PEPFAR ‘is not the best use of international health funding’ and ‘fails to address many of the developing world's most serious health issues’ . Among the arguments presented by Denny and Emanuel for diverting funding away from PEPFAR include the contention that PEPFAR fails to focus on children based on the premise that ‘Levels of attention and effort directed at preventing the small proportion of child deaths owing to AIDS with a new, complex, and expensive intervention seem…to be outstripping the efforts to save millions of children every year’ [2,3].
Although we welcome the Mother and Child Campaign in a diverse portfolio of global health strategies funded by the United States, we are troubled by the ‘either/or’ mentality that places HIV/AIDS funding in direct opposition to initiatives to improve MCH. We do not accept the premise by Denny and Emanuel that the proportion of child deaths owing to AIDS is ‘small,’ nor do we support the characterization of HAART as ‘new, complex, and expensive’ [2,3]. We would argue that policies based on misrepresentations such as these threaten to undermine rather than support MCH worldwide.
HIV affects children, mothers, families, and healthcare workers
In the five countries with the highest adult HIV prevalence worldwide, HIV is the single leading cause of under-five mortality and responsible for 41–56% of deaths (Table 1) . In many other countries in Sub-Saharan Africa, death certificate misclassifications underestimate mortality attributed to HIV/AIDS by as much as 53.1% [5,6] because the cause of death is often classified as the AIDS-related opportunistic infection without reference to HIV .
Despite the potential inaccuracies in HIV/AIDS statistics that underestimate prevalence and mortality, absolute HIV numbers are not decreasing. One thousand children were born with HIV everyday in 2007, due in part to the fact that less than 25% of all HIV-positive women worldwide have access to prevention of mother-to-child transmission . Of children born with HIV today in Africa, only 20% are expected to survive until their second birthday without HAART .
HIV-positive children are not the only victims of this epidemic. All children born to HIV-positive mothers (who, in some regions of Africa, constitute 25% of childbearing women) are at a higher risk for morbidity and mortality if maternal-HIV is not treated effectively . Longitudinal data on 3468 children of HIV-positive mothers in Africa found that uninfected children whose HIV-positive mothers gave birth ‘at an advanced disease stage’ were at significantly higher risk of death . This may be attributable in part to the fact that children with HIV-positive caregivers reside in food-insecure households more often than their unaffected peers [9–11], putting them at higher risk for malnutrition and death from diarrhea and acute respiratory infection . Caregiver death from HIV is also associated with poor outcomes for HIV-uninfected children, resulting in a (3–4X) fold increase in mortality [8,13].
Even more broadly, the AIDS epidemic impacts the healthcare systems in areas where children live. In Southern Africa, where HIV prevalence is the highest worldwide, HIV-related diseases monopolize more than half of all hospital beds [14,15]. Healthcare workers are not exempt from the epidemic. A study in Zambia found that 40% of midwives were HIV-positive  and estimates place seroprevalence rates for all healthcare workers in South Africa at approximately 16% . Far from endangering MCH, devoting resources to untreated HIV will also necessarily improve the quality of care available to all mothers and children.
HAART saves lives and money
Two reviews of HAART among HIV-infected children in Sub-Saharan Africa demonstrate that good immunologic, virologic, and clinical outcomes can be achieved despite the limitations of resource-limited settings [18,19]. Nutritional status improved, hospital admissions decreased by 58–71%, incidence of diarrhea decreased by 64%, and incidence of pneumonia decreased by 56% . Twenty-eight studies reported ‘significant immunological reconstitution’ and probability of survival after 1 year of therapy was 84–97% .
Treating HIV-positive adults has been shown to positively impact the family as a whole, even those members who are not HIV-positive themselves. When HIV-positive adults were provided with cotramoxazole prophylaxis alone, mortality among HIV-negative household members of 10 years or less decreased by 63% . Malaria, diarrhea, and hospitalizations also decreased . Parental HAART access provides even more dramatic results: HAART implementation resulted in ‘sharp improvements in (child) nutritional status,’  and HAART and cotramoxazole were associated with an 81% reduction in mortality in their uninfected children less than 10 years .
There is also an intimate link between HIV and maternal health. A study by Hogan et al. estimated that in the absence of HIV, there would have been a 17.9% reduction in maternal mortality in 2008. Dr Murray, the senior author of the study, states: ‘It means, to us, that if you want to tackle maternal mortality in those regions, you need to pay attention to the management of HIV in pregnant women. It is not about emergency obstetrical care, but about access to antiretrovirals’ .
Unfortunately, only one-third of patients who qualify for HAART in resource-limited settings are able to access it [7,23]. Recently, the WHO revised guidelines for HAART initiation; an estimated five million HIV-infected patients would now qualify for treatment with the new guidelines . Flat-lining PEPFAR funding increases would, in essence, constitute ‘treatment rationing’ for the millions of patients dying of this entirely treatable illness .
Recent literature has suggested that the cost of inaction is substantially greater than the cost of HAART. The cost-effectiveness arguments asserted by Denny and Emanuel  in favor of MCH initiatives over HIV treatment are misleading. Hogan et al. conclude that HAART provides ‘good value for money…in terms of broad measures of population health outcomes.’ Several studies show that failure to use HAART is even more expensive than HAART itself; the Brazilian Ministry of Health, having implemented a program of universal HAART access, reported savings of more than 2.2 billion US dollars between 1997 and 2001 alone . A study from Côte d'Ivoire  noted that starting treatment earlier shows even more financial benefit, providing a savings of $1180 for every year of life saved.
The indirect value of HAART is difficult to quantify, but no less important. It has been theorized that HAART may serve an important role in preventing HIV, both by lowering viral loads in HIV-positive persons  and by encouraging people to present for voluntary counseling and testing. Furthermore, numerous studies have demonstrated that access to HAART has been pivotal in helping communities overcome denial, stigma, and discrimination . HAART may support healthcare infrastructure by allowing healthcare personnel to report more regularly to work [25,29]. HAART has contributed to the reduction in absenteeism in the workplace and to greater economic growth and development [30,31] in addition to reducing the financial burden that orphanhood places on communities and governments.
The President's Emergency Plan for AIDS Relief and primary healthcare systems: synergies and opportunities
We and others propose that HIV/AIDS Global Health Initiatives (GHIs) such as PEPFAR can advance and synergistically reinforce MCH and the overall healthcare infrastructure of the recipient country [24,32,33,35]. The WHO Maximizing Positive Synergies Collaborative Group has studied the interactions between GHIs and country health systems in detail, and report many positive associations between HIV/AIDS GHIs and their effects on strengthening primary healthcare systems .
In addition to improving outcomes for families infected and affected by HIV, PEPFAR has supported the care and treatment for milieu-specific diseases other than HIV/AIDS. Funding from PEPFAR has revitalized health facilities, increased the availability of qualified healthcare personnel, and enabled the expansion of ancillary support services such as pharmacies and diagnostic laboratories. TB and malaria have received funding ($4 billion and $5 billion, respectively) and infrastructure support from PEPFAR as well [34,35].
Two concrete examples of synergy between PEPFAR and MCH are Rwanda and Haiti. The original PEPFAR authorization of 2003 included HIV scale-up funding for countries such as Rwanda and Haiti where adult HIV prevalence was less than 3% . According to the WHO, the highest causes of morbidity and mortality in both Rwanda and Haiti were attributed to diarrheal diseases, respiratory infections, and/or maternal/obstetric/neonatal complications and not HIV/AIDS . In fact, clinical outcome studies have demonstrated that PEPFAR has directly and indirectly led to better MCH health outcomes in both countries.
A study in Rwanda demonstrated that PEPFAR dollars ‘contributed to broader health services, including reproductive health, prenatal, and pediatric services’ [35–38]. Two months after HAART was provided at seven Rwandan PEPFAR sites, the average number of new hospital admissions dropped by 21%, allowing those healthcare facilities to focus on the other disease burdens of the community [37,38].
In Haiti, HIV-specific GHIs have led to an increase in primary healthcare services including vaccinations, family planning, and TB [32,39]. A severe limitation in the resource-limited setting is the availability of trained healthcare workers , but an innovative model pioneered in Haiti recruited and trained lay community health workers (CHWs) to assist patients with HIV/TB disease management including medication adherence . Results were impressive; HIV prenatal seroprevalence decreased from 5 to 2.7% over 5 years with a treatment attrition rate of 2% . Jerome and Evers  report that the recruitment of CHWs initially to support HIV/TB treatment has resulted in the ‘diagonal expansion of the health workforce at a community level’ toward other diseases including MCH.
Despite the evidence that disease-specific GHIs can reinforce MCH and the overall primary healthcare of recipient countries, several challenges remain. GHIs must aspire for better integration, resource-allocation, and accountability within the host country's healthcare system; too often duplication of health objectives owing to lack of communication between providers of health aid have contributed to a proliferation of parallel systems .
HIV/AIDS is a significant threat to the health of families worldwide. It is a major cause of under-5 mortality and is intimately connected with MCH. The impact of PEFPAR on this epidemic goes well beyond treating the HIV positive individual and to limit PEPFAR funding would be a threat to the well being of families and communities in resource-limited settings.
In a speech to the parliament of Ghana, President Obama described US global health strategy in this way: ‘We will carry forward the fight against HIV/AIDS. We will pursue the goal of ending deaths from malaria and tuberculosis…and we won't confront illnesses in isolation – we will invest in public health systems that promote wellness and focus on [MCH]’ . We urge President Obama to reaffirm his presidential campaign promise of expanding PEPFAR by $1 billion/year in new money over the next 5 years while also supporting MCH.
Confronting illness in isolation – whether by funding PEPFAR at the expense of programs that target MCH or vice versa – cannot be our way forward. Integrated health service delivery models that address the well being of both HIV-positive and HIV-negative families, without prioritizing one at the expense of the other must be developed, funded, and implemented. Similarly, family-centered models should be expanded to protect the integrity of caregiving structures by preventing the decline in health or death of primary caregivers while also improving pediatric health outcomes [41–43]. The complex and interrelated challenges of MCH against the devastating global backdrop of HIV require comprehensive models of care that combine HIV/AIDS and MCH initiatives.
S.C.L. and A.R. are medical students at Brown University and the University of Colorado, respectively. Prior to matriculating to medical school both authors assisted the PEPFAR-funded Sinikithemba HIV/AIDS clinic at McCord Hospital in Durban, South Africa. Their research was funded independent of PEPFAR. Our hosts at McCord Hospital (A.R.) and the Children's Rights Centre (S.C.L.) provided inspirational mentorship.
A.R. thanks Michael Weinstein (President of the AIDS Healthcare Foundation), Gretchen Heinrichs MD, and Taylor M. Triolo for providing critical debate and discussion that contributed to the genesis and framework of this paper. A.R.'s contribution toward this publication is in partial fulfillment of his Mentored Scholarly Activity thesis requirement at the University of Colorado.
A Lewis Hine Documentary Fellowship from Duke University and the Bernard van Leer Foundation supported S.C.L. A J. William Fulbright Scholarship and additional support from the University of Michigan, College of Literature, Science, and the Arts and the University of Colorado, School of Medicine supported A.R.
A.R. and S.C.L. contributed equally to drafting this manuscript; both authors reviewed and approved the final draft.
S.L. and A.R. assisted a PEPFAR-funded antiretroviral clinic in South Africa. Their research was funded independent of PEPFAR.
Conflict of interest disclosure: A.R. is on the board of directors of the AIDS Healthcare Foundation (AHF). The opinions expressed are the authors' own and do not necessarily represent any position or policy of AHF.
2. Denny CC, Emanuel EJ. US health aid beyond PEPFAR
: the Mother & Child Campaign. JAMA 2008; 300:2048–2051.
3. Jones G, Steketee RW, Black RE, Bhutta ZA, Morris SS. How many child deaths can we prevent this year? Lancet 2003; 362:65–71.
4. World Health Organization. Mortality profiles by country: World Health Statistics 2006
. Geneva: World Health Organization; 2006. http://www.who.int/whosis/mort/profiles/en/
. [Accessed 25 April 2010]
5. Nojilana B, Groenewald P, Bradshaw D, Reagon G. Quality of cause of death certification at an academic hospital in Cape Town, South Africa
. S Afr Med J 2009; 99:648–652.
6. Yudkin PL, Burger EH, Bradshaw D, Groenewald P, Ward AM, Volmink J. Deaths caused by HIV
disease under-reported in South Africa
7. 2008 Report on the global AIDS
epidemic. Geneva: UNAIDS, 2008. http://www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport/2008/2008_Global_report.asp
. [Accessed 25 April 2010]
8. Newell ML, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F. Mortality of infected and uninfected infants born to HIV
-infected mothers in Africa
: a pooled analysis. Lancet 2004; 364:1236–1243.
9. Alkenbrack BSE, Forsythe S, Martin G, Chettra T. Confirming the impact of HIV/AIDS epidemics on household vulnerability in Asia: the case of Cambodia.AIDS
10. Cornia G. Overview of the impact and best practice responses in favour of children in a world affected by HIV/AIDS
. Florence: UNICEF-IDRC; 2002.
11. Niang CI, Van Ufford PQ, Cornia GA. The socio-economic impact of HIV/AIDS on children in a low prevalence context: the case of Senegal.
Florence: UNICEF-IRC; 2002.
12. Rice AL, Sacco L, Hyder A, Black RE. Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries. Bull World Health Organ 2000; 78:1207–1221.
13. Mermin J, Were W, Ekwaru JP, Moore D, Downing R, Behumbiize P, et al
. Mortality in HIV
-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV
-uninfected children: a prospective cohort study. Lancet 2008; 371:752–759.
14. 2006 Report on the global AIDS
epidemic. Geneva: UNAIDS, 2006. http://www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport/2006/
. [Accessed 24 April 2010]
15. Ferrand RA, Bandason T, Musvaire P, Larke N, Nathoo K, Mujuru H, et al
. Causes of acute hospitalization in adolescence: burden and spectrum of HIV
-related morbidity in a country with an early-onset and severe HIV
epidemic: a prospective survey. PLoS Med 2010; 7:e1000178.
16. HIV/AIDS and work: global estimates, impact and response
. Geneva: International Labor Organization; 2004.
17. Shisana O. High HIV
prevalence among health workers requires urgent action. S Afr Med J 2007; 97:108–109.
18. Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. Effectiveness of antiretroviral therapy among HIV
-infected children in sub-Saharan Africa
. Lancet Infect Dis 2008; 8:477–489.
19. Ciaranello AL, Chang Y, Margulis AV, Bernstein A, Bassett IV, Losina E, Walensky RP. Effectiveness of pediatric antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis. Clin Infect Dis 2009; 49:1915–1927.
20. Thirumurthy Z, Zivin JG, Goldstein M. The economic impact of AIDS treatment: labour supply in Western Kenya
. Economic Growth Center Discussion Paper No 947. New Haven: Yale University; 2006.
21. Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, et al
. Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5. Lancet 2010; 375:1609–1623.
22. Grady G. A maternal deaths decline sharply across the globe The New York Times
. [Accessed 13 April 2010]
23. Ford N, Mills E, Calmy A. Rationing antiretroviral therapy in Africa
: treating too few, too late. N Engl J Med 2009; 360:1808–1810.
24. Katzenstein D, Koulla-Shiro S, Laga M, Moatti JP. Learning and doing: operational research and access to HIV treatment in Africa.AIDS
25. Hogan DR Baltussen R, Hayashi C, Lauer JA, Salomon JA. Cost effectiveness analysis of strategies to combat HIV/AIDS in developiong countries.BMJ
26. 2004 Report on the global AIDS
epidemic. Geneva: UNAIDS, 2006. http://www.unaids.org/bangkok2004/gar2004_html/GAR2004_00_en.htm
. [Accessed 24 April 2010]
27. Goldie S YY, Losina E, Weinstein M, Xavier A, Walkensy R et al.Clinical benefits and cost-effectiveness of antiretroviral therapy for HIV-infected patients in resource-poor settings: the case of Côte d'Ivoire.XVI International AIDS Conference
28. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV
testing with immediate antiretroviral therapy as a strategy for elimination of HIV
transmission: a mathematical model. Lancet 2009; 373:48–57.
29. Deghaye N, Pawinski RA, Desmond C. Financial and economic costs of scaling up the provision of HAART
-infected healthcare workers in KwaZulu-Natal. S Afr Med J 2006; 96:140–143.
30. Marseille E, Saba J, Muyingo S, Kahn JG. The costs and benefits of private sector provision of treatment to HIV
-infected employees in Kampala, Uganda. AIDS
31. Gonzalo T, Garcia Goni M, Munoz-Fernandez MA. Socio-economic impact of antiretroviral treatment in HIV
patients: an economic review of cost savings after introduction of HAART
Rev 2009; 11:79–90.
32. Samb B, Evans T, Dybul M, Atun R, Moatti JP, Nishtar S, et al
. An assessment of interactions between global health
initiatives and country health systems. Lancet 2009; 373:2137–2169.
33. Walensky RP, Kuritzkes DR. The impact of the President's Emergency Plan for AIDS
) beyond HIV
and why it remains essential. Clin Infect Dis 2010; 50:272–275.
34. Henry J. Kaiser Family Foundation. Reauthorization of PEPFAR, the United States Leadership against HIV/AIDS, Tuberculosis, and Malaria Act: a side-by-side comparison to current law.http://www.kff.org/hivaids/upload/7799.pdf
. [Accessed 25 April 2010]
35. Mayer KH, Hamilton CD. Distributing US health aid. JAMA 2009; 301:1339–1340, author reply 1340.
36. Piot P, Kazatchkine M, Dybul M, Lob-Levyt J. AIDS
: lessons learnt and myths dispelled. Lancet 2009; 374:260–263.
37. Price JE, Leslie JA, Welsh M, Binagwaho A. Integrating HIV
clinical services into primary healthcare in Rwanda: a measure of quantitative effects. AIDS
Care 2009; 21:608–614.
38. Price J. Integrating HIV clinical services in primary healthcare centers in Rwanda: effect on the quantity on non-HIV services delivered. HIV Implementers Meeting
; 17 June 2007; Kigali, Rwanda.
39. Jerome G, Ivers LC. Community health workers in health systems strengthening: a qualitative evaluation from rural Haiti.AIDS
40. Obama B. A new moment of promise in Africa.http://www.whitehouse.gov/blog/A-New-Moment-of-Promise-in-Africa/
. [Accessed 18 July 2009]
41. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, et al
. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa
. BMC Pediatr 2007; 7:13.
42. Reddi A, Leeper SC. Antiretroviral therapy adherence in children: outcomes from Africa
43. Reddi A, Leeper SC, Sunpath H. Pediatric highly active antiretroviral therapy in Africa
: potential benefits of a family-centered model. J Infect Dis 2008; 198:938–939, author reply 939–940.