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Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

van Manen, Daniëlle; Kootstra, Neeltje A; Boeser-Nunnink, Brigitte; Handulle, Muna AM; van 't Wout, Angélique B; Schuitemaker, Hanneke

doi: 10.1097/QAD.0b013e328338a16c

Dept Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA) at the Academic Medical Center of the University of Amsterdam; 1105AZ Amsterdam, The Netherlands.

We recently demonstrated that two single nucleotide polymorphisms (SNPs), namely rs9264942 in the HLA-C gene region and rs2395029 in the HCP5 gene region, were both associated with the clinical course of HIV-1 infection in participants of the Amsterdam Cohort Studies (ACS) [1]. These SNPs were originally identified in a genome-wide association analysis using set-point HIV-1 viral load as a phenotype [2].

After publication of our manuscript, the 335 participants of the ACS that were included in our study were retyped for the dimorphism 35 kb upstream of the HLA-C gene (-35 C/T; rs9264942), using a predeveloped assay based on ABI TaqMan allelic discrimination-based technology and an ABI7900 Sequence Detection System (ABI, Foster City, CA). With this assay, the rs9264942 genotype was different from our earlier results for 45 individuals (42 were typed CT instead of TT, 2 were typed TT instead of CT, and one person was typed CT instead of CC). The genotype distribution is 164 TT, 139 CT, and 32 CC, which is within Hardy Weinberg Equilibrium (P = not significant). This changed genotype distribution did not alter the overall conclusion of our manuscript, although P values for the association of this genotype with the clinical course of HIV-1 infection did change slightly. We refer to the adjusted P values in the new figures and tables that are available as supplementary information, We sincerely apologize for this error.

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1. van Manen D, Kootstra NA, Boeser-Nunnink B, Handulle MA, van't Wout AB, Schuitemaker H. Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection. AIDS 2009; 23:19–28.
2. Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, et al. A whole-genome association study of major determinants for host control of HIV-1. Science 2007; 317:944–947.

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