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Evaluation of a peer support group therapy for HIV-infected adolescents

Funck-Brentano, Isabellea; Dalban, Cécileb; Veber, Florencea; Quartier, Pierrea; Hefez, Sergea; Costagliola, Dominiqueb; Blanche, Stéphanea

doi: 10.1097/01.aids.0000183124.86335.0a
EPIDEMIOLOGY AND SOCIAL
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Objective: To assess the effects of a peer support group therapy on HIV-infected adolescents.

Design: A prospective study of a cohort of HIV-infected adolescents participating or not participating in a psychodynamic oriented, emotional support group.

Methods: From a group of 30 perinatally HIV-infected adolescents who attended an outpatient clinic, 10 agreed to participate in the peer support group (group 1), 10 declined (group 2) and 10 others who lived too far from the clinic were not invited to participate (group 3). The three groups were compared at baseline and 2 years later using the outcome measures: perceived illness experience scale, perceived treatment inventory, self-esteem inventory.

Results: At baseline, the three groups had similar characteristics overall. The adolescents’ self-esteem was in the normal range. After 2 years, worries about illness had decreased in group 1, whereas the scores had increased or remained the same for the other adolescents (P = 0.026). The adolescents in group 1 had less negative perception of treatment at 2 years than those in groups 2 and 3 (P = 0.030). After intervention, the percentage of adolescents with an undetectable viral load had increased in group 1 from 30 to 80% (P = 0.063) but was unchanged in groups 2 and 3. Considering the three groups altogether, the decrease in the viral load correlated with improvement of the perceived treatment inventory (Spearman R = 0.482 P = 0.015).

Conclusions: This pilot study suggests that a peer support group intervention is associated with an improvement in adolescents’ emotional well being, and that this can have a positive influence on medical outcomes.

From the aUnité d'Immunologie-hématologie pédiatrique, Hôpital Necker-Enfants Malades, Paris

bEMI 0214 INSERM, Université Pierre et Marie Curie, Paris, France.

Received 7 January, 2005

Revised 14 April, 2005

Accepted 20 April, 2005

Correspondence to Stéphane Blanche, Unité d'Immunologie-hématologie pédiatrique, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris cedex 15, France. E-mail: blanche@necker.fr

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Introduction

Advances in treatment have transformed pediatric HIV disease into a chronic illness, and consequently a large proportion of patients have reached adolescence and adulthood [1,2]. Although most are in a good clinical condition thanks to antiretroviral therapy, they report general life-threatening chronic illness and psychological distress. Youths with HIV sometimes have additional risk factors, including any of disrupted home life, family history of mental illness and substance abuse, cumulative experience of death, disclosure and danger of rejection [3–6]. A high incidence of psychiatric symptoms has also been reported [7–10].

Social, psychological and treatment issues in adolescents infected in early infancy may differ from those for youths infected through adult behaviors. Adolescents who have experienced a long history of HIV infection accumulate a number of potential difficulties with peers, with self-image [11], sexuality, future academic and occupational plans, and planning for life as an adult with a job and a family [12]. Most patients taking long-term treatment develop side-effects from the medications or develop a psychological resistance to adhering to the medication regime, or both [13–18].

The psychological manifestations of the disease have been studied. These studies focused on the course of the disease and the patients’ psychological adjustment to it; for example, negative life events and fear of disclosure of diagnosis [6,12,19–27]. Recent research highlights the potential impact of psychosocial intervention and peer support on coping and emotional well-being [28–34]. Other group therapy interventions for HIV-infected adolescents are often education oriented either to increase adherence to medications or to encourage safe sex [35–37].

Psychosocial intervention appears to be more relevant and potentially more effective for the serious psychological problems that are associated in these patients. Such treatment could help them deal with the pressure of various individual and social difficulties which heighten isolation behaviors, negative self image and poor adherence to treatment. This study prospectively evaluates the impact of a peer support group therapy on a cohort of adolescents, all HIV1-infected in early infancy and followed in a pediatric University-tertiary hospital.

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Methods

Subjects

A total of 48 HIV-infected adolescents (12 to 18 years old) were followed in our clinic during the study period (1999–2003). The adolescents had to fulfill five criteria to be eligible for the study: (1) HIV infection either by mother-to-child transmission or perinatal transfusion; (2) name of the virus and transmission route known by the patient; (3) evidence of self motivation to participate in a peer support group; (4) no previous participation in a therapy group; and (5) adolescent's and guardian's agreement to participate in the study. Thirty-eight adolescents met the criteria, and 23 were invited to join the group therapy. They divided themselves spontaneously into two groups: 10 chose to participate in the group therapy (group 1) and 13 declined (group 2). Finally, a third group was defined as the 15 other patients who were living too far from Paris to be offered participation (group 3). The three groups were invited to complete the same questionnaires before the beginning of the group therapy (T0) and again 2 years later when the group therapy was over (T2). Only adolescents who participated at both time points were considered in the analyses. Consequently, eight adolescents were excluded from the final analysis because they moved or subsequently refused to participate during the study period. Consequently, our subject population was made up of 30 adolescents. To avoid stressing the adolescents of group 2, reasons for refusal were not systematically discussed; the main reason was denial of any problem or needs concerning these issues.

During the study period, the adolescents participating in the group therapy did not participate in any other individual or group therapy (group 1). In the two other groups, six adolescents had received individual psychotherapy in the past and 10 continued to see a therapist occasionally.

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Group therapy setting

Adolescents met for a 90-min session once every 6 weeks for 26 months. The format was open-ended. The number of adolescents fluctuated from one session to the next. Recently referred adolescents fulfilling the selection criteria joined the group after its initiation. Adolescents were allowed to withdraw at any time on the condition that they explain why. The group was led by two therapists, a man and a woman, both trained in psychodynamic and family therapy. Each session was transcribed.

The intervention consisted of unstructured discussions. The participants were invited to determine their own focus themes for each meeting and encouraged to discuss their feelings spontaneously. The therapeutic process involved:

  1. establishing the clinical setting;
  2. fostering group cohesiveness, and trust;
  3. enabling members to share individual experiences and feelings;
  4. fostering individuality, safety when expressing, being a giver or receiver of help;
  5. promoting change and forming clear reachable individual goals;
  6. working with group processes and managing a productive termination.
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Variables and measures

Medical data included clinical condition, usual biological variables (CD4 lymphocytes and viral load) and patient's adherence as subjectively perceived by the pediatrician.

Social and family characteristics included age, sex, and country of origin, whether or not the biological parents were alive, type of caregiver, and school/academic level.

The study explored three psychological areas from the adolescent's perspective.

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Perceptions of the infection/disease

Perceptions of the infection/disease were collected using the Perceived Illness Experience Scale (PIE) (C. Eiser, 1995), designed for adolescents of 12 years of age and older with cancer [38]. The questionnaire is composed of 40 items which assess, each using a five-point scale, how much the illness interferes with 10 areas of the adolescent's daily living. The subscales assess the extent to which respondents feel their appearance has been affected (Physical Appearance); feel the illness and treatment limit recreational activities (Interference with Activity); dislike thinking or talking about illness (Disclosure); have school- or work-related difficulties (School); feel alienated from their peers (Peer Rejection); feel their parents are overprotective (Parental Behavior); use the illness as an excuse to get out of things (Manipulation); are preoccupied with the illness (Preoccupations); and have difficulties related to eating (Food). An additional subscale, which determines the impact of treatment, was developed for our population to explore the impact of the parent's infection/disease on the adolescents (Parents’ Health). The PIE was translated into French. Three items related to physical appearance changes specifically due to chemotherapy were inappropriate for our population. We therefore modified them to focus on the effect of AIDS or antiretroviral therapy on physical appearance. Each subscale score is between 4 and 20 and the total score between 40 and 200. A high score means that the adolescent meets major difficulties with health in various areas. The internal reliability and validity of the PIE has been demonstrated [38,39].

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Perceptions of treatment

A questionnaire on perceptions of treatment, the Perceived Treatment Inventory (PTI), was developed for this study, because such instruments focusing on HIV were not available to us. Items from the questionnaire were derived from interviews with patients and from the not yet published Beliefs about Medicine Scale (BAMS) designed by Riekert [40]. It consists of 11 items which describe, on a five-point scale, four areas of the adolescent's perceptions regarding: (1) compliance; (2) fears and beliefs regarding adverse effects, both physical and psychological; (3) complications in day-to-day routines; and (4) family and social support. For each area a subscale score was calculated: (1) from 1 to 5; (2) and (4) from 3 to 15 and (3) from 4 to 20. The total score is thus between 11 and 55. A high score means that treatment generates a variety of serious problems.

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Self-esteem

The self-esteem variable was studied using the French version of the Self-Esteem Inventory (SEI) [41,42]. This self-report questionnaire consists of 58 items to which the patient indicates whether the statement is «like me» or «unlike me». The items measure four domains: global self-esteem, familial satisfaction, peer relationships, and adjustment to school. An additional lie scale explores whether the respondent is trying to make the investigator think the respondent is perfect. Reference mean scores were: total score = 33.35, general subscale score = 18.64, social subscale score = 5.67, family subscale score = 4.92, school subscale score = 4.12, and lie subscale score = 2.38.

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Ethical procedure

All the adolescents and their legal guardians had given their consent to participation, in compliance with French regulations.

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Statistics

Our patients, 48 adolescents, were patients recently referred to the clinic, or followed at the clinic since early infancy.

At baseline the subjects were described by comparing group 1 with groups 2 and 3 using χ2 or Fisher's exact test for categorical variables and the Mann–Whitney test for continuous variables.

Psychological questionnaires missing more than 10% of the items were excluded from analysis. For the valid questionnaires, missing items in the Perceived Illness Experience Scale and Perceived Treatment Inventory were replaced by the mean of the other subjects’ scores for the same item, and those in the Self Esteem Inventory were replaced by a number randomized between 0 and 1 according to the distribution of the valid item. Thus, the scores were calculated with no missing items.

At baseline, all the scores and subscale scores were described by using median and range. Kolmogorov–Smirnov tests were used for comparing the distributions of the total scores between groups 1 and 2, and between groups 1 and 3.

The change in score between baseline and year 2 was calculated and this delta score was compared with the Kolmogorov–Smirnov tests between groups 1 and 2, and between groups 1 and 3. Comparisons were also made between year 2 and baseline by using tests for matched comparisons: the Wilcoxon test for the score and MacNemar test for the prevalence of undetectable viral load.

Analyses were performed using SPSS (version 11.5) for Windows (SPSS Inc., Chicago, Illinois, USA).

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Results

Baseline description

Demographics and medical components

The three groups had similar demographic and medical characteristics (Table 1). The median age of the entire study population was 14.2 years (range, 12.0–17.4 years). Sixty per cent were living with their biological parent(s), 23% with extended family and 17% with foster parents. All the adolescents were attending school regularly.

Table 1

Table 1

Only two adolescents were symptomatic at time of assessment. Ninety per cent received antiretroviral therapy. Adherence to treatment was considered by the medical team as not optimum in 11% of the adolescents.

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Adolescents’ self-perceptions

Perceived Illness Experience Scale

No significant difference was found for the total score between the three groups at T0 (Table 2). The only difference was that the parents’ behavior subscale score was higher for group 1 than for group 2 (P = 0.022). The overall median for total score was 81 (range, 55–140), which represents evidence of difficulties with the illness. All three groups had high scores for Disclosure and Preoccupations subscales with an overall median of 14 (range, 6–20) and 10 (range, 4–20), respectively. These results indicate that disclosure issues and various preoccupations about health were major sources of worry and distress. Parents’ health and eating were also concerns with an overall median of 9 for both. The adolescents scored low on two subscales: School (4), and Interference with Activity (6), suggesting that HIV infection did not interfere in these two domains.

Table 2

Table 2

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Perceptions of treatment

The median total score and the median for the four subscales are presented in Table 3. The overall median total score was 19.50 [range, 11–37], an indication that the participants had trouble with their medications. However, most of the adolescents scored low on the compliance score describing themselves as good in their compliance behavior. Complications in day-to-day routines scored high in the three groups, (median, 10; range, 4–14), meaning that the adolescents’ medication difficulties were related to daily obligations and to frequent obstacles and nuisances. Group 1 complained significantly more than group 2 about family interference in taking medication and about lack of support from their friends (P < 0.026).

Table 3

Table 3

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Self-esteem

All but two adolescents had mean or above scores for the total and four subscales. Although not significantly different, the three groups were not identical: the adolescents who had refused to participate in the group therapy (group 2) had the highest score for the four domains of self-esteem and the lie subscale (score 6 versus reference mean score 2.38). This shows an inclination to overestimate their image and to deny their difficulties.

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Evolution after 2 years

Adolescents’ self-perceptions

The results are presented in Tables 2 and 3. Total scores of the Perceived Illness Inventory showed a decrease in preoccupations about illness for group 1 but an increase in group 2 (comparisons of the two distributions using the Kolmogorov–Smirnov test, P = 0.026). In group 1, the total score for preoccupations about illness decreased by 14 points between T0 and T2 (Δ = –14), but for group 2, the total score increased (Δ = +3); this difference was statistically significant (Wilcoxon test P = 0.017). Preoccupations remained the same over time in group 3. Group 1 had less negative perceptions of medication than group 3 after 2 years (P = 0.030) and the negative perceptions of treatment decreased significantly in group 1 (P = 0.042). The fears and beliefs score about medication increased over time in groups 2 (P = 0.007) and 3 (P = 0.029) but decreased in group 1 (P = 0.06, for the difference with group 2). Finally the Coopersmith self-esteem questionnaire scores for the three groups were similar.

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Medical components

All the adolescents remained in a good clinical condition during the study period. Treatment for all children was prescribed according to current international guidelines without interference for the psychosocial support. The same number of subjects was receiving antiretroviral treatment at baseline and 2 years later. The number of subjects in group 1 with an undetectable viral load increased from 30 to 80% over the two years, and approached but did not reach statistical significance (MacNemar χ2, P = 0.063); the numbers of such subjects in the two other groups remained unchanged (Table 4). For the study population as a whole, the change in the Perceived Treatment Inventory score correlated with the decrease in the viral load (Spearman R = 0.482 P = 0.015, Fig. 1.). No significant change in CD4 cell count was observed (data not shown).

Table 4

Table 4

Fig. 1

Fig. 1

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Discussion

This pilot study suggests that the peer support group had a beneficial effect on the adolescents’ acceptance and perceptions of their HIV infection. The findings even suggest that this improvement in well-being could have a positive influence on biological variables. To our knowledge, these are the first evaluations of a peer group support intervention on HIV-infected adolescents’ well-being [29,43].

As there was no instrument for use to assess the perception by the HIV patients of their illness, we chose an instrument that focused on pediatric cancer patients as the basis. With the modification of only a few items we adapted the PIE for our purposes. Our results with the PIE agree with current self-report of our HIV-infected adolescents. In our study, preoccupations about health and disclosure issues scored the highest among the ten subscale scores. Many adolescents feel that it is unfair that they have become HIV-infected and they fear the disease's effect on the rest of their lives. As a consequence, they dislike talking about their health and try to avoid the subject. On the other hand, half of the adolescents who were offered participation in the group therapy joined the group. This indicates that, despite reluctance to talk about their health to others, they were motivated to share their difficulties with HIV-infected peers. The total score on the PIE significantly decreased in the therapy group between T0 and T2. There was no such decrease for the two other groups. Moreover, the changes in group 1 and group 2 between T0 and T2 were significantly different: Total score increased over time in the group of adolescents who refused to participate in the group therapy whereas it decreased in the adolescents who attended the group therapy. At baseline, the adolescents who chose to join the group therapy were experiencing significantly more difficulties with their parents’ overprotective behavior than those who refused to participate. It is possible that parents’ anxieties regarding their child increased the pressure on an already anxious adolescent. This may contribute to the motivation for these adolescents to attend a peer support group, where they expect to find relief by sharing their experiences with their peers. Perhaps they benefited from the way their peers helped them reframe and cope with HIV.

The adaptation of items in the PTI seemed appropriate, considering the adolescents’ responses. Although validation of the inventory with psychometric properties would be valuable, comparisons with the Beliefs about Medicine Scale – Adolescent version (BAMS) [40] should be used to improve the relevance and the psychometric properties of the measure. In the PTI results, there is some evidence that the opportunity to interact with HIV-infected peers had a positive influence on the adolescents’ perceptions of treatment; the total score in group 1 decreased as did the fears and beliefs subscale score. Moreover, at baseline, the adolescents who chose to join the group therapy complained more about parental interference with medication and were more interested in help from their peers than those who refused to participate. (See PIE parent subscale score.)

Surprisingly, the adolescents scored in the normal range on the SEI and were comparable to normative data reported for healthy adolescents. Similar results were found on SEI scores in adolescents with cancer [44], and in asthmatic children [45,46]. Studies using the SEI measure have shown that adolescents’ low score on self-esteem were associated with experience of loneliness, isolation and dejection [47], with divorced parents [48,49], with anxiety related to poor quality home environment [50] and for girls, with maternal depression status [51] and quality of interactions with their mothers [52]. The HIV-infected adolescents are at risk of fulfilling several of these criteria. We expected them to score lower on self-esteem than the average healthy population. Surprisingly all but two scored in the normal range. This indicates that despite the difficulties associated with HIV-infection, our study population was able to develop good self-esteem. Similarly, the Peer Rejection subscale score in the PIE was low, suggesting that peer relationship experiences were not significantly poor in our study population. However, at baseline, adolescents who refused to participate in the group therapy scored well above the mean on the lie subscale score, a result suggesting that adolescents in group 2 attempted to give a falsely good image of themselves. It also suggests that the adolescents who refused to participate in the therapy group were coping with illness by denial.

The improvement trend of the viral load in group 1 is promising. There was a correlation between the PTI and the variations of the viral load for the study population as a whole, suggesting that any intervention which could improve adolescents’ positive perception of antiretroviral therapy could be of benefit for treatment adherence.

The psychological profile of HIV-infected adolescents in the future will be different from those described here: early therapy will bring major changes in the adolescents’ history as well as their perceptions of their parent's HIV status. The absence of severe illness in their experience and the better prognosis of the infection may result, in the coming decades, in adolescents neglecting both optimum adherence to medication regimens as well as safe, non-transmission behaviors. There will be a continuing need to address general emotional distress, psychosocial maladjustment and safe behaviors.

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Acknowledgements

We would like to thank Professor Christine Eiser for the permission to use the Perceived Illness Experience Scale.

Sponsorship: This work was supported by a grant from the Agence Nationale de Recherche contre le Sida (ANRS).

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References

1. Martino M, Tovo PA, Balducci M, Galli L, Gabiano C, Rezza G, et al. Reduction in mortality with availibility of antiretroviral therapy for children with perinatal HIV-1 infection. Italian Register for HIV Infection in Children and the Italian National AIDS Registry. JAMA 2000; 12:190–197.
2. Gortmaker SL, Hughes M, Cervia J, Brady M, Johnson GM, Seage GR, et al. Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected witth HIV-1. N Engl J Med 2001; 22:1522–1528.
3. Brown LK, Lourie KJ. Children and adolescents living with HIV and AIDS: a review. J Child Psychol Psychiatr 2000; 41:81–96.
4. Rogers AS, Futterman DK, Moscicki AB, Wilson CM, Ellenberg J, Vermund SH. The REACH Project of the Adolescent Medicine HIV/AIDS Research Network: Design, methods and selected characteristics of participants. J Adolesc Health 1998; 22:300–311.
5. Frederick T, Thomas P, Mascola L, Hsu HW, Rakusan T, Mapson C, et al. Human immunodeficiency virus-infected adolescents: a descriptive study of older children in New York City, Los Angeles County, Massachusetts and Washington DC. Pediatr Infect Dis 2000; 19:551–555.
6. Bachanas PJ, Kullgren KA, Schwartz KS, Lanier B, McDaniel JS, Smith J, et al. Predictors of psychological adjustment in school-age children infected in HIV. J Pediatr Psychol 2001; 26:343–352.
7. Havens JF, Whitaker AH, Feldman JF, Ehrhardt AA. Psychiatric morbidity in school-age children with congenital human immunodeficiency virus infection: a pilot study. J Dev Behav Pediatr 1994; 15:S18–S25.
8. Pao M, Lyon M, D'Angelo LJ, Schuman WB, Tipnis T, Mrazek DA. Psychiatric diagnoses in adolescents seropositive for the human immunodeficiency virus. Arch Pediatr Adolesc Med 2000; 154:240–244.
9. Misdrahi D, Vila G, Funck-Brentano I, Tardieu M, Blanche S, Mouren-Simeoni MC. DSM-IV mental disorders and neurological complications in children and adolescents with human immunodeficiency virus type 1 infection (HIV-1). Eur Psychiatry 2004; 19:182–184.
10. Gaugham DM, Hughes MD, Oleske JM, Malee K, Gore CA, Nachman S, Pediatric AIDS Clinical Trials Group 219C Team. Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection. Pediatrics 2004; 113:e544–e551.
11. Chapman L. Body image and HIV: implications for support and care. AIDS Care 1998; 10:S179–S189.
12. Battles HB, Wiener LS. From adolescence through young adulthood: psychosocial adjustment associated with long-term survival of HIV. J Adolesc Health 2002; 30:161–168.
13. Kingäs HA, Kroll T, Duffy ME. Compliance in adolescents with chronic diseases: a review. J Adolesc Health 2000; 26:379–388.
14. Dolezal C, Mellins C, Brackis-Cott, Abrams EJ. The reliability of reports of medical adherence from children with HIV and their adult caregivers. J Ped Psychol 2003; 28:355–361.
15. Van Dyke RB, Lee S, Johnson GM, Wiznia A, Mohan K, Stanley K, et al. Reported adherence as a determinant of responses to highly active antiretroviral therapy in children who have human immunodeficiency virus infection. Pediatrics 2002; 109:e61.
16. Murphy DA, Wilson CM, Durako SJ, Muenz LR, Belzer M. Adolescent Medicine HIV/AIDS Research Network. AIDS Care 2001; 13:27–40.
17. Murphy DA, Sarr M, Durako SJ, Moscicki AB, Wilson CM, Muenz LR. Adolescent Medicine HIV/AIDS Research Network. Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. Arch Pediatr Adolesc Med 2003; 157:249–255.
18. Naar-King S, Frey M, Harris M, Arfken C. Measuring adherence to treatment in pediatric HIV/AIDS. AIDS Care 2005; 17:345–349.
19. Moss H, Bose S, Wolters P, Brouwers P. A preliminary study of factors associated with psychological adjustment and disease course in school-age children infected with the human immunodeficiency virus. J Dev Behav Pediatr 1998; 19:18–25.
20. Funck-Brentano I, Costagliola D, Seibel N, Straub E, Tardieu M, Blanche S. Patterns of disclosure and perceptions of the human immunodeficiency virus in infected elementary school-age children. Arch Pediatr Adolesc Med 1997; 151:978–985.
21. Grassi L, Righi R, Makoui S, Sighinolfi L, Ferri S, Ghinelli F. Illness behavior, emotional stress and psychosocial factors among asymptomatic HIV-infected patients. Psychother Psychosom 1999; 68:31–38.
22. Howland LC, Gortmaker SL, Mofenson LM, Spino C, Gardner JD, Gorski H, et al. Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. Pediatrics 2000; 106:540–546.
23. Missmer SA, Spiegelman D, Gorbach SL, Miller TC. Predictors of change in the Functional status of children with Human Immunodeficiency virus infection. Pediatrics 2000; 106:1–7.
24. Murphy DA, Moscicki AB, Vermund SH, Muenz LR. Psychological distress among HIV(+) adolescents in the REACH study: effects of life stress, social support, and coping. The Adolescent Medicine HIV/AIDS Research Network. J Adol Health 2000; 27:391–398.
25. Sherman BF, Bonanno GA, Wiener LS, Battles HB. When children tell their friends they have aids: possible consequences for psychosocial well-being and disease progression. Psychosom Med 2000; 62:238–247.
26. Lester P, Chesney M, Cooke M, Weiss R, Whalley P, Perez B, et al. When the time comes to talk about HIV: factors associated with diagnostic disclosure and emotional distress in HIV-infected children. J Acquir Immune Defic Syndr 2002; 31:309–317.
27. Mellins CA, Smith R, O'Driscoll P, Magder LS, Brouwers P, Chase C, et al. High rates of behavioral problems in perinatally HIV-infected children are not linked to HIV disease. Pediatrics 2003; 111:384–393.
28. Kelly JA. Group psychotherapy for persons with HIV and AIDS-related illnesses. Int J Group Psychother 1998; 48:143–162.
29. Plante WA, Lobato D, Engel R. Review of group interventions for pediatric chronic conditions. J Pediatr Psychol 2001; 26:435–453.
30. Bacha R, Pomeroy EC, Gilbert D. A psychoeducational group intervention for HIV-positive children: a pilot study. Health Soc Work 1999; 24:303–306.
31. Parsons JT, Butler R, Kocik S, Norman L, Nuss R. The role of the family system in HIV risk reduction: youths with hemophilia and HIV infection and their parents. Adolescent Hemophilia Behavioral Intervention Evaluation Project (HBIEP) Study Group. J Pediatr Psychol 1998; 23:57–65.
32. Kmita G, Baranska M, Niemec T. Psychosocial intervention in the process of empowering families with children living with HIV/AIDS-a descriptive study. AIDS Care 2002; 14:279–284.
33. Rotheram-Borus MJ, Lee MB, Gwadz M, Draimin B. An intervention for parents with AIDS and their adolescents children. Am J Public Health 2001; 91:1294–1302.
34. Rotheram-Borus MJ, Lee M, Lin YY, Lester P. Six-year intervention outcomes for adolescent children of parents with human immunodeficiency virus. Arch Pediatr Adolesc Med 2004; 158:742–748.
35. Lyon ME, Trexler C, Akpan-Townsend C, Pao M, Selden K, Fletcher J, et al. A family group approach to increasing adherence to therapy in HIV-infected youths: results of a pilot project. AIDS Patient Care STDS 2003; 17:299–308.
36. Rotheram-Borus MJ, Miller S. Secondary prevention for youths living with HIV. AIDS Care 1998; 10:17–34.
37. Brown LK, Schultz JR, Parsons JT, Butler RB, Forsberg AD, Kocik SM, et al. Sexual behavior change among human immunodeficiency virus-infected adolescents with hemophilia. Adolescent Hemophilia Behavioral Intervention Evaluation Project Study Group. Pediatrics 2000; 106:e22.
38. Eiser C, Havermans T, Craft Akernahan J. Development of a measure to assess the perceived-illness experience after treatment for cancer. Arch Dis Child 1995; 72:302–307.
39. Eiser C, Kopel S, Cool P, Grimer R. The Perceived Experience Scale (PIE): reliability and revisited. Child Care Health Dev 1999; 25:179–190.
40. Riekert KA, Drotar D. The beliefs about medication scale: developments, reliability and validity. J Clin Psychol Med Settings 2002; 9:177–184.
41. Coopersmith S. Self-esteem Inventory. Palo Alto (CA): Consulting Psychologists Press; 1981.
42. Coopersmith S. Self-esteem Inventory (traduction et adaptation française). Paris: Edition du Centre de Psychologie Appliquée; 1984.
43. Drotar D, Lemanek K. Steps toward a clinically relevant science of interventions in pediatric settings: introduction to the special issue. J Pediatr Pychol 2001; 26:385–394.
44. Ritchie MA. Self-esteem and hopefulness in adolescents with cancer. J Pediatr Nurs 2001; 16:35–42.
45. Heilveil I, Schimmel B. Self-esteem in asthmatic children. J Asthma 1982; 19:253–254.
46. Vila G, Nollet-Clemencon C, de Blic J, Mouren-Simeoni MC, Scheinmann P. Prevalence of DSM IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents. J Affect Disord 2000; 58:223–231.
47. Haines DA, Scalise JJ, Ginter EJ. Relationship of loneliness and its affective elements to self-esteem. Psychol Rep 1993; 73:479–482.
48. Brubeck D, Beer J. Depression, self-esteem, suicide ideation, death anxiety, and GPA in high school students of divorced parents and nondivorced parents. Psychol Rep 1992; 71:755–763.
49. Bynum MK, Durm MW. Children of divorced parents and its effect on their self-esteem. Psychol Rep 1996; 79:447–450.
50. Kawash GF. A stuctural analysis of self-esteem from pre-adolescence through young adulthood: anxiety and extraversion as agents in the development of self-esteem. J Clin Psychol 1982; 38:301–311.
51. Miller L, Warner V, Wickramaratne P, Weissman M. Self-esteem and depression: ten year follow-up of mothers and offspring. J Affect Disord 1999; 52:41–49.
52. Lackovic-Girgin K, Dekovic M, Opacic G. Pubertal status, interaction with significant others, and self-esteem of adolescents girls. Adolescence 1994; 29:691–700.
Keywords:

HIV1; adolescent; psychotherapy group; program evaluation; attitude to health; self concept; highly active; antiretroviral therapy; viral load

© 2005 Lippincott Williams & Wilkins, Inc.