Treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy (HAART) partially corrects the immune defects caused by chronic HIV infection. It was apparent that this included restoration of protective pathogen-specific immune responses shortly after the introduction of HAART because opportunistic infections were reported to resolve . This has resulted in a sharp decline in the prevalence of opportunistic infections in HIV patients . Furthermore, studies of the effect of HAART on cytomegalovirus (CMV) viraemia and CMV-specific CD4 T-cell responses [3,4] have provided direct evidence that HAART enhances protective pathogen-specific immune responses.
Suppression of HIV viraemia by antiretroviral therapy is accompanied by atypical ‘opportunistic infections’ or other inflammatory diseases in some patients. When these conditions were first reported, there was uncertainty about whether they were a consequence of the restoration of an immune response against opportunistic pathogens, or opportunistic infections resulting from residual defects of cell-mediated immunity [5–9]. Subsequently, there has been acceptance that they are a consequence of immune reconstitution in patients who experience a virological response to HAART. These conditions have previously been reviewed [10–15], although there has been a divergence of opinion about nomenclature and there continues to be uncertainty about pathogenic mechanisms and management. Here, we argue that atypical ‘opportunistic infections’ after commencing HAART are the consequence of restoring an immune response against the antigens of opportunistic pathogens that is immunopathological rather than protective. These conditions are therefore considered to be immune restoration disease (IRD) rather than immunodeficiency disease.
Sarcoid-like disease and autoimmune diseases are observed less frequently in patients responding to HAART and also appear to have an immunological basis. These conditions will also be considered as IRD. However, there is a need to differentiate the different types of IRD and we will consider them under the headings of infectious IRD, sarcoid IRD and autoimmune IRD.
As the use of HAART increases around the world, physicians managing patients with HIV infection will encounter increasing numbers of patients with IRD. Management of these conditions is often problematic, in particular their differentiation from opportunistic infections or drug toxicity. It is therefore important to understand the immunopathogenesis of IRD so that diagnostic criteria and prevention and treatment strategies can be developed.
Infectious immune restoration disease
The observation of atypical presentations of Mycobacterium avium complex (MAC) disease in patients treated with zidovudine monotherapy was the first indication that restoring pathogen-specific immune responses can cause immunopathology . MAC disease in this situation was localized rather than disseminated and was characterized by severe fever, painful lesions and a granulomatous inflammatory response or suppuration. Most importantly, it was associated with restoration of cutaneous delayed-type hypersensitivity (DTH) responses to mycobacterial antigens, whereas MAC disease before antiretroviral therapy had invariably been associated with anergy. Furthermore, subsequent loss of DTH responses to mycobacterial antigens was associated with the occurrence of disseminated MAC infection .
MAC IRD in patients responding to HAART presents with fever, lymphadenitis, pulmonary infiltrates or inflammatory masses [6,17–26]. Pyomyositis and cutaneous abscesses have also been described . MAC IRD usually occurs during the first three months of therapy in patients with pre-therapy CD4 T-cell counts < 100 × 106 cells/l. Lymphadenitis is often painful and may suppurate. Inflammatory masses are usually endobronchial but may affect the abdominal cavity. Histological examination of lymph nodes or inflammatory masses often reveals granulomatous inflammation. MAC is usually cultured from lesions but not from the blood. Cutaneous DTH responses to mycobacterial antigens are a characteristic finding [6,19,25].
Restoration of cellular immune responses to Mycobacterium tuberculosis (MTB) antigens may also cause IRD in patients responding to HAART [28–36]. MTB IRD is associated with the restoration of a cutaneous DTH response to tuberculin [28,29,34]. It presents within the first 2 months of HAART, usually in the first 2–3 weeks. Common presenting features are severe fever, intra-thoracic and cervical lymphadenopathy and pulmonary infiltrates. Extra-thoracic disease is less common and includes focal cerebritis [6,30], pleural effusions, hepatosplenomegaly and ascites . Pulmonary disease may be associated with hypercalcaemia .
Bacille Calmette-Guerin (BCG) lymphadenitis in a child, which was associated with a DTH response to tuberculin , and borderline tuberculoid leprosy  have also been described in patients responding to HAART.
Several lines of evidence indicate that mycobacterial IRD results from a DTH response to mycobacterial antigens. Granulomatous inflammation and tissue necrosis are typical of DTH responses . Foudraine et al.  showed that MAC disease after HAART was associated with increased lymphoproliferation responses to mycobacterial antigens. The occurrence of MAC IRD and, to our knowledge, the lack of virus-associated IRD after zidovudine monotherapy supports the involvement of DTH because zidovudine monotherapy is sufficient to augment DTH responses . Finally, a case study showed a correlation between MAC IRD and DTH responses to tuberculin in a patient who never had CD4 T-cell deficiency .
The basic elements of managing mycobacterial IRD are anti-mycobacterial and anti-inflammatory therapies. Corticosteroids are usually used but pentoxyphylline may be effective for MTB IRD .
Soon after the introduction of HAART, it was observed that some patients presented with an initial or recurrent episode of cryptococcal meningitis during the first few weeks of therapy . It occurred in patients with CD4 T-cell counts < 50 × 106 cells/l who had an immunological and virological response to HAART and was characterized by a more prominent inflammatory cell reaction in the CSF than in patients not receiving HAART. Cryptococci were usually cultured from CSF and/or blood. Subsequently, Jenny-Avital et al. reported that 50% of patients with cryptococcal infection who responded to HAART developed cryptococcal disease despite the use of fluconazole therapy . However, cryptococcal disease in this series of patients presented 2 to 11 months after commencing HAART and was characterized by failure to culture cryptococci even though organisms were seen in lesions or cryptococcal antigen was detected in body fluids. Reports on other individuals or small series of patients have shown similar findings and a pattern of clinical presentation of late cryptococcal IRD is emerging.
The most common presentation of late cryptococcal IRD is lymphadenitis, particularly mediastinal lymphadenitis [43–46]. It is reported to present up to 15 months after commencing HAART . Histological examination of nodes may reveal granulomatous inflammation, necrosis or suppuration. Granulomatous inflammation may be associated with hypercalcaemia . Cryptococcal IRD of the central nervous system (CNS) has also been described. Aseptic meningitis is associated with high intracranial pressure [43,47] and localized inflammatory lesions may occur in the spinal cord  or brain .
There are no known data showing that cryptococcal disease in patients responding to HAART is associated with increased immune responses to cryptoccocal antigens. However, an interpretation of the available clinical data suggests that effective HAART may result in two types of inflammatory reaction to cryptoccoci. Firstly, an acute inflammatory reaction to subclinical meningeal infection during the first few weeks of therapy and secondly, a chronic inflammatory reaction in lymph nodes or the CNS, possibly initiated by a T-cell response to the antigens of non-viable cryptoccoci.
The optimal management of cryptococcal IRD has not been defined. Anti-inflammatory therapy has been used  but many cases resolve spontaneously.
Pneumocystis carinii pneumonitis that has improved on anti-Pneumocystis therapy may relapse following the introduction of HAART [50–52]. Commencement of HAART within 18 days of commencing anti-Pneumocystis therapy and/or cessation of corticosteroid therapy appear to be risk factors, but only a limited amount of data are available.
Hepatitis B and C virus IRD
Hepatotoxicity is an adverse effect of HAART in up to 18% of patients. This is a direct effect of antiretroviral drugs, particularly nevirapine and high-dose ritonavir, in some patients but hepatotoxicity occurs most often in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) co-infection (for example see [53–55]). The pathogenesis of hepatotoxicity in HIV/HCV or HIV/HBV co-infected patients has not been defined, but early clinical studies suggested IRD might be a cause [56,57].
Liver biopsies in HIV/HCV co-infected patients with HAART-associated hepatotoxicity show changes of viral hepatitis [54,57], suggesting that there has been an immune response against the HCV. However, the association of hepatotoxicity with increased blood CD4 T-cell counts is controversial [54,55,58] and there are no known data on HCV-specific T-cell responses. Studies of pathogenic mechanisms may require the use of liver biopsy samples or serological markers to demonstrate the role of HCV-specific immune responses because the cellular immune response in HCV-associated hepatitis is compartmentalized to the liver . For example, HAART-associated hepatotoxicity is associated with increased plasma levels of HCV antibodies [57,60,61] and dipeptidyl dipeptidase IV [DPP IV, soluble (s) CD26] activity . sCD26 (DPP IV) is an aminopeptidase which down-regulates CXCR3 , a major homing molecule expressed by Th1 cells in the HCV-infected liver .
Although HAART-associated hepatotoxicity in HIV/HCV co-infected patients may result in fulminant hepatitis and sometimes cirrhosis [64,65], this is very uncommon . The outcome for most patients appears to be similar to patients who do not experience hepatotoxicity [66,67]. However, the long- term effect of hepatotoxicity on liver fibrosis is currently unknown and it has been argued that HCV infection should be treated before commencing HAART to reduce the probability of hepatotoxicity .
HAART-associated hepatotoxicity in HIV/HBV co-infected patients is associated with a decreased plasma HIV RNA level and increased CD4 T-cell count, and liver biopsies show changes of viral hepatitis [56,69–73]. In some patients, hepatotoxicity was associated with clearance of HBeAg and HBV DNA and increased anti-HBc and anti-HBe [56,70,73] whereas in others it was associated with increased plasma levels of HBV DNA, reappearance of HBsAg, loss of anti-HBs and appearance of anti-HBcIgM [69,71,72]. An explanation for the dichotomous immunological and virological effects of HAART in HIV/HBV co-infected patients with hepatotoxicity is not available. Clearly, further studies are needed to elucidate pathogenic mechanisms.
Eye disease is the most common presentation of CMV IRD. It presents as retinitis in the first 3 months of HAART or as uveitis, usually much later than retinitis. CMV retinitis IRD may be the first indication of CMV infection [74,75], or present as a relapse of established CMV retinitis that is in remission on anti-CMV therapy [6,76] and subsequently resolves without relapse when anti-CMV therapy is ceased . It occurs in patients with CD4 T-cell counts < 100 × 106 cells/l who experience an increased CD4 T-cell count in response to HAART. A positive plasma CMV polymerase chain reaction was a strong predictor of CMV retinitis in a prospective study of patients commencing protease inhibitor therapy .
Immune recovery uveitis (IRU) is an inflammatory disorder that affects eyes with inactive CMV retinitis in patients who have experienced an increased CD4 T-cell count on HAART [78–81]. It presents with floaters and/or impaired visual acuity and can result in permanent visual impairment. The inflammatory changes may include vitritis, papillitis, cystoid macular oedema and epiretinal membranes. Fibrovascular membranes resulting from the inflammation may be misdiagnosed as recurrent CMV retinitis . Karavellas et al.  reported that IRU presents 2–84 (median 20) weeks after an increase in the CD4 T-cell count. Eyes with an average CMV retinitis area of > 30% had a 4.5-fold increased risk of developing IRU. The incidence was estimated to be 0.83/person-year. However, this is much greater than the rate of 0.109/person-year reported in another study . IRU can cause severe inflammatory eye disease and, therefore, patients on HAART with a previous history of CMV retinitis who develop visual symptoms must be assessed by an ophthalmologist. Topical or systemic corticosteroid therapy is usually effective.
First presentations or relapses of CMV retinitis after commencing HAART appear to represent the effects of an immune response against retinal CMV infection that eventually controls the infection. However, Hsieh et al.  showed that CMV-specific CD4 T-cell responses were lower in patients who developed CMV retinitis after commencing HAART compared with patients without retinitis. We and others [84,85] have shown that CD4 T-cell responses to CMV antigens remain low in all patients with nadir CD4 T-cell counts of < 50 × 106 cells/l during the first year of HAART. However, we have also shown that CMV retinitis after HAART is associated with increased plasma levels of IgG anti-CMV antibody and soluble (s) CD30  and with increased bioavailable interleukin (IL)-6 . Our interpretation of these findings is that the immune response restored against CMV antigens in patients with CMV retinitis IRD is immunopathological and characterized by a Th2 bias and/or a CD8 T-cell response because CD30 is expressed by Th2 cells and has a regulatory function in CD8 cytolytic T cells . With regard to this, Hsieh et al.  showed that CMV-specific CD8 T-cell responses in patients with CMV retinitis after HAART are similar to patients without retinitis, indicating that there is a relative predominance of CD8 over CD4 CMV-specific T-cell responses in patients who develop retinitis.
Examination of epiretinal membranes from eyes with IRU demonstrated the presence of chronic inflammatory cells consisting predominantly of T cells . Preliminary evidence suggests that the inflammation represents a CMV-specific CD8 T-cell response. Thus, cloning of T cells from the vitreous fluid of a single patient demonstrated a predominance of CMV-specific CD8 T cells  and the severity of IRU is not related to the magnitude of the increase in blood CD4 T cells .
Varicella zoster virus IRD
Rates of varicella zoster virus (VZV) disease are increased in patients responding to HAART. Dermatomal VZV disease occurs in 6–8% of patients at a rate of 6.2–9.0 episodes per 100 patient years [6,90–92]. The rate has been estimated to be five times higher than expected . The majority of cases present during the first 4 months of HAART but some cases present much later.
Studies by two Spanish groups have identified a greater increase in CD8 T-cell counts as a risk factor for dermatomal VZV disease after HAART [91,92], suggesting that CD8 T cells may be mediating an immune response against VZV antigens. A case study of transverse myelitis resulting from VZV IRD demonstrated that NK cells as well as CD8 T cells may be mediating a response to VZV antigens . Of note, the immune response in that case was compartmentalized to the CNS, indicating that IRD may occur in the absence of immune reconstitution in the blood.
VZV IRD responds to acyclovir therapy [6,91,92] suggesting that the immune response is against active VZV infection. However, VZV stromal keratitis has also been reported as an IRD in a patient receiving prophylactic acyclovir therapy .
Herpes simplex virus IRD
Data from an observational study suggests that mucocutaneous herpes simplex virus (HSV) disease may occur more frequently and be more severe in patients responding to HAART . In addition, Fox et al.  reported chronic penile ulceration related to HSV infection in black African men. Of note, all three affected patients carried HLA-B72, -Cw0202 and -DRB4, suggesting that there is a genetic susceptibility to this condition. Presumptive HSV infection has been associated with encephalomyelitis after HAART .
JC virus IRD
HAART is the only effective therapy for progressive multifocal leukoencephalopathy (PML) in HIV patients , probably because it augments CD4 T-cell responses to JC virus (JCV) antigens . However, in some patients who commence HAART, PML may become worse or present for the first time [96,98–103]. Cinque et al.  reported that 18% of patients with PML experienced an exacerbation within 9 weeks of commencing HAART associated with a reduction of the plasma HIV RNA level and an increased CD4 T-cell count. Antiretroviral-naive patients responding to HAART had the worst outcome with 50% experiencing progression of PML lesions. Histopathology examination of lesions demonstrates more inflammation than in lesions from patients not receiving HAART. In particular, perivascular infiltrations of lymphocytes, monocytes and plasma cells have been observed [99,101–103]. The lymphocytes are predominantly CD8 T cells [99,101], suggesting that CD8 T cells may mediate an immunopathological response to JCV antigens. Supporting evidence has been provided by a case study of a patient who developed PML after responding to HAART without an increase in the blood CD4 T-cell count .
Evidence-based guidelines for the prevention and management of JCV IRD are not available. However, there is preliminary evidence that modification of the antiretroviral regimen might have a beneficial effect. In the series of patients reported by Cinque et al. , a better outcome was observed in patients who interrupted therapy or used a drug regimen that resulted in slower immune reconstitution. Corticosteroid therapy has been used to treat JCV IRD but may be ineffective [101,102].
Uncommon infectious IRD
There are several case reports of IRD associated with uncommon opportunistic pathogens. These are listed in Table 1.
Disease in patients responding to HAART that might be infectious IRD
Other diseases associated with an infection by an opportunistic viral pathogen are reported to present atypically or more frequently in patients responding to HAART. The evidence that they are IRD is not as strong as for the conditions discussed so far, but they are discussed to promote further study of their pathogenesis because an immunopathological response to the virus might be involved.
Two publications documenting an increase in the prevalence of oral warts in the context of a decrease in Candida stomatitis, hairy leukoplakia and Kaposi's sarcoma of the mouth in patients on HAART [111,112] raise the possibility of human papillomavirus IRD. Non-Hodgkin's lymphoma (NHL) after commencing HAART  might be related to an immunopathological response to Epstein Barr virus (EBV) infection, as T-cell responses to some EBV antigens induce IL-10 production  and increased IL-10 production is associated with HIV-associated NHL . Finally, reports that Kaposi's sarcoma  or multicentric Castleman's disease  develop after commencing HAART suggest a possible immunopathological response to human herpes virus-8.
Risk factors for infectious IRD
Collation of the clinical, immunological and immunogenetic data presented over the last 12 years has identified risk factors for infectious IRD that could be used in a risk assessment for patients commencing HAART (Fig. 1). Firstly, an active or subclinical infection by opportunistic pathogens , or the antigens of non-viable micro-organisms (eg. cryptococci and CMV) are all possible targets for an immunopathological response. This may explain why prophylactic anti-MAC therapy may not prevent MAC IRD . Secondly, a CD4 T-cell count below 50 × 106 cells/l is a major risk factor for IRD . It may be a marker of a high pathogen load and/or an increased susceptibility to immune dysregulation during immune reconstitution. Finally, there are disease susceptibility genes for some IRD. The first indication of this was that some patients with CMV retinitis presenting as IRD also experienced neurological disease associated with definitive or presumptive infection by other herpes viruses . This suggested a genetic susceptibility to an immunopathological response against herpes viruses. Supportive evidence has been provided by our studies showing that HLA-B44 and the major histocompatibility complex (MHC) ancestral haplotype HLA-A2, -B44, -DR4 , and allele 1 at a single nucleotide polymorphism (SNP) in the 3′UTR of the IL12B gene encoding IL-12 p40  are associated with herpes virus IRD. The significance of these findings was strengthened by the observation that alleles of other cytokines genes (TNFA-308*2 and IL6-174*G) were not associated with herpesvirus IRD but were associated with mycobacterial IRD.
Diagnosis of infectious IRD
If advances are to be made in the diagnosis and management of infectious IRD, it is essential that diagnostic criteria are formulated and tested in clinical practice. Proposed diagnostic criteria are outlined in Table 2. These are based on the findings of a retrospective study  and the many clinical studies referred to in this review. A diagnosis of IRD would require both major criteria or criterion A and two minor criteria.
Sarcoid immune restoration disease
Granulomatous inflammation of the lungs, which has the characteristics of sarcoidosis, has been described in patients responding to HAART [121–127]. Granulomatous inflammation of other organs has also been described, including the skin [122,128,129; and Fig. 2a], kidneys, liver and duodenum . In a study undertaken on patients presenting to five pneumonology departments, Foulon et al.  reported that cases presented from 3 to 43 months after commencing HAART. HIV-associated sarcoidosis has been reported in patients not receiving HAART  but this is characterized by a CD8 T-cell alveolitis whereas sarcoid IRD is associated with an intense CD4 T-cell alveolitis and a CD4 T-cell infiltrate in granulomas [121,127]. The involvement of CD4 T cells in the pathogenesis of sarcoid IRD may explain the occurrence of this disorder after the addition of interleukin-2 therapy to HAART [121,124,127]. It is important to exclude infectious IRD as a cause of granulomatous inflammation because this may occur in patients infected by mycobacteria, cryptococci (see above) and histoplasma (Fig. 2b).
Sarcoid IRD may resolve spontaneously with continuation of HAART but corticosteroid therapy is sometimes necessary .
Autoimmune immune restoration disease
Autoimmune diseases presenting for the first time, or as an exacerbation of established disease, have also been reported in HIV patients responding to HAART. Patients with systemic lupus erythematosus, polymyositis or rheumatoid arthritis usually present during the first few months therapy [131–134]. A patient with relapsing polychondritis and sarcoidosis presented after 2 years . It is presumed that the immune dysregulation underlying the autoimmune disease is precipitated or exacerbated by the immunological changes that occur after suppression of HIV replication. Guillain–Barre syndrome may also present in the first few weeks of HAART [135,136]. CD8 T cells were demonstrated in the endoneurium of brachial plexus nerves in one patient .
Graves’ disease is an uncommon but well-recognized complication of immune reconstitution in severely immunodeficient HIV patients [137,138]. It presents later than other autoimmune diseases in patients on HAART and probably has a different pathogenic mechanism. A case study has provided evidence that it may result from thymic dysfunction during immune reconstitution .
Miscellaneous immune restoration diseases
The pathogenesis of several disparate disorders in patients responding to HAART is unclear but immunological mechanisms appear be involved (Table 3).
Immune restoration disease in developing countries
Antiretroviral therapy is gradually being introduced into developing countries through the activities of agencies such as Medecins Sans Frontieres (MSF) and the Global Fund to Fight AIDS, Tuberculosis and Malaria. In one report on 743 patients in a MSF programme, all patients had baseline CD4 T-cell counts of < 200 × 106 cells/l and the median count was 48 × 106 cells/l . There were therefore many patients at risk of developing infectious IRD. During an observation period of between 1.7 and 6.9 months, 8.2% of patients died, of whom 42.6% died during the first 30 days of therapy. While this may have reflected opportunistic infections complicating residual immunodeficiency, the findings of another study suggest that it may have been IRD. In a prospective study of 60 Thai patients with treated cryptococcal meningitis commencing HAART with CD4 T-cell counts between 0 and 147 × 106 cells/l, 20 episodes of ‘opportunistic infection’ occurred in 14 (23%) patients . These occurred between 4 and 32 (median 16) weeks after commencing HAART and were associated with increased CD4 T cell counts. Disease was associated with infections by MTB, MAC, cryptococci, Toxoplasma, VZV and HSV and there were two deaths.
The increasing use of HAART in developing countries and late presentation of HIV patients in some developed countries  will inevitably result in a large number of severely immunodeficient patients being given HAART. There will therefore be many patients at-risk of developing IRD. Although some IRD are short-lived or cause minor clinical problems, others may result in significant morbidity and sometimes death. Infectious IRD of the central nervous system is of particular concern because it may result in permanent neurological disability or death [6,93,96,102,104].
Strategies should therefore be devised to prevent IRD. In patients about to commence a new HAART regimen, these might include identification of patients with risk-factors for infectious IRD (see Fig. 1) so that subclinical infection by opportunistic pathogens can be excluded, or measures taken to reduce pathogen load in patients with an opportunistic infection. However, the potential benefits of delaying HAART to prevent IRD in patients receiving treatment for an opportunistic infection might be outweighed by the risk of developing another opportunistic infection if HAART is delayed. This issue should be examined in prospective clinical studies.
The development of new therapeutic approaches for IRD requires a better understanding of pathogenic mechanisms. It has become clear that infectious IRD has two patterns of presentation. Early IRD presents during the first 3 months of HAART and appears to result from an immune response against viable opportunistic pathogens, which are often present as a subclinical infection. An exception may be VZV IRD, which sometimes presents later than 3 months because VZV infection reactivates infrequently . Late IRD presents month to years after commencing HAART and appears to result from an immune response against the antigens of non-viable opportunistic pathogens. Cryptococcal lymphadenitis and CMV IRU are good examples of this. Anti-microbial therapy is unlikely to be effective. Late IRD would appear to be different to the opportunistic infections, such as localized MAC infection [149,150], that occur infrequently in patients who had nadir CD4 T-cell counts of < 50 × 106 cells/l and cease prophylaxis because their CD4 T-cell count has increased on HAART. This type of disease is characterized by isolation of viable pathogens and is probably the result of an immune defect that has not been corrected by HAART, which might include deficiency of type 1 cytokines .
Finally, it has become clear that the immunopathological response to different pathogens has different pathogenic mechanisms. Mycobacterial and fungal IRD appear to be the result of a DTH response whereas IRD associated with viruses, such as herpes viruses and JCV, appear to result from a CD8 T-cell response. The association of mycobacterial and herpes virus IRD with polymorphisms in the genes encoding different cytokines  provides further evidence of different types of immune response. The long-term effect of these immunopathological responses is unclear. The increase in plasma bioavailable IL-6 in patients with CMV retinitis IRD persists for at least 4 years , which may partly explain the elevation of plasma IL-6 levels in patients with a previous history of IRD . Mycobacterial IRD may also increase the plasma IL-6 level  but the effect is transient. The immunological and metabolic consequences of increased IL-6 production deserve further attention as it might contribute to persistent immune activation in patients with well-controlled HIV replication on HAART  or to the pathogenesis of type 2 diabetes , which is increasingly being recognized as a long-term complication of HAART .
We are grateful to Dr Kate Clezy and Dr Jeffrey Post for contributions to Table 2 and to Dr Cecily Metcalf for providing Fig. 2b.
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