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Are HIV drug advertisements contributing to increases in risk behavior among men in San Francisco, 2001?

Klausner, Jeffrey Da; Kim, Andreab; Kent, Charlottea

RESEARCH LETTERS
Free
SDC

aSan Francisco Department of Public Health, STD Prevention and Control Services, and bAIDS Office, San Francisco, California, USA.

Sponsorship: This work was supported by the City and County of San Francisco.

Received: 10 May 2002; revised: 6 June 2002; accepted: 21 June 2002.

In winter 2001, we quantified exposure to HIV medication direct-to-consumer advertising and its relationship to attitudes and behaviors among sexually transmitted disease clinic attendees. We found that homosexual men frequently saw HIV medication advertisements. HIV-positive homosexual men with greater advertisement exposure believed HIV was a less serious disease. Men believed these advertisements influenced an individual's decision to have unprotected sex. HIV-positive homosexual men with greater advertisement exposure may be more likely to have unprotected anal intercourse.

Several studies have suggested that HIV treatment optimism may play a role in increasing the rates of unsafe sex among gay men and men who have sex with men [1–4]. Whereas direct-to-consumer (DTC) advertising campaigns for antiretrovial HIV drugs strive to increase the awareness of the potential benefits of HIV therapy, there may be untoward effects of this DTC advertising. A recent publication described ‘what Americans are being sold in direct-to-consumer (DTC) advertisements for prescription drugs', but failed to quantify the effects that DTC advertisements may have in specific populations [5]. We sought to quantify these effects in a population with potential high exposure to certain DTC advertising, and measured the relationship between exposure and reported attitudes and behaviors.

From February to July 2001, we surveyed men attending the San Francisco municipal sexually transmitted disease (STD) clinic regarding sexual practices, HIV status, exposure to HIV pharmaceutical advertisements and attitudes towards the seriousness of HIV and a decision to have unprotected sex. The survey was an anonymous, self-administered convenience sample of 997 men, 53% of whom were heterosexual. We compared results between heterosexual (n = 527) and homosexual men (n = 466) and between homosexual men by HIV status (HIV negative 300; HIV positive 75) by frequency of exposure to HIV pharmaceutical advertisements. We defined seeing advertisements at least weekly as frequent exposure versus monthly, rarely or never seeing advertisements as infrequent exposure. The mean age of respondents was 32 years, 49% were white and 84% had completed at least some college education.

Among homosexual men, 76% reported seeing HIV drug advertisements that portrayed men who are healthy, handsome and strong either daily or weekly versus only 38% in heterosexual men (P < 0.05). Whereas the frequency of exposure did not appear to affect men's belief in the seriousness of HIV by sexual orientation, HIV-positive homosexual men who saw advertisements at least weekly were six times more likely to believe that HIV was less serious compared with HIV-positive homosexual men who saw advertisements less frequently (36 versus 6%, P < 0.03).

Regardless of sexual orientation, those with more frequent exposure to the advertisements were more likely to agree that the advertisements affected an individual's decision to have unprotected sex compared with men with less exposure (63 versus 42% in homosexual and 69 versus 56% in heterosexual men, P < 0.01, respectively). In addition, among HIV- positive homosexual men with frequent advertisement exposure, 58% reported that these advertisements affected an individual's decision to have unprotected sex versus only 13% in those less frequently exposed (P < 0.01).

Finally, we found no difference between homosexual and heterosexual men in reported unprotected vaginal or anal sex by advertisement exposure. Within homosexual men, however, HIV-positive respondents with frequent advertisement exposure more often reported unprotected anal sex compared with HIV-positive respondents with infrequent exposure (27 versus 17%, P < 0.4).

We concluded that during the survey period homosexual men in San Francisco seen at the municipal STD clinic were frequently exposed to HIV pharmaceutical advertisements. HIV-positive homosexual men with greater exposure to the advertisements believed that HIV is a less serious disease, and both heterosexual and homosexual men believed that these advertisements influence an individual's decision to have unprotected sex. Finally, HIV-positive homosexual men with greater exposure to these advertisements may be more likely to engage in unprotected anal intercourse.

This study demonstrated that DTC HIV pharmaceutical advertising affects health beliefs at the population level and may influence individual behaviors. Subsequent to the preliminary report of these data, the Food and Drug Administration issued an advisory letter to HIV pharmaceutical manufacturers instructing them to change DTC materials to convey that HIV medications neither cure HIV infection nor reduce its transmission, and that individual medications must be taken only in combination with other drugs for HIV infection. Furthermore, the Food and Drug Administration letter stated that the images used in DTC promotional activities must be generally representative of patients with HIV infection and must not minimize significant side-effects.

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References

1.Dilley J, Woods W, McFarland W. Are advances in treatment changing views about high risk sex?N Engl J Med 1997, 337:501–502.
2.Van de Ven P, Kippax S, Knowx G, Prestage X, Crawford J. HIV treatments optimism and sexual behavior among gay men in Sydney and Melbourne.AIDS 1999, 13:2295–2298.
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5.Woloshin S, Schwartz LM, Tremmel J, Welch HG. Direct-to-consumer advertisements for prescription drugs: what are Americans being sold?Lancet 2001, 358:1141–1146.
© 2002 Lippincott Williams & Wilkins, Inc.