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IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy

Sortino, Ornellaa,b,*; Richards, Elizabethb,*; Dias, Joanac; Leeansyah, Edwinc,d; Sandberg, Johan, K.c,*; Sereti, Irinib,*

doi: 10.1097/QAD.0000000000001760
Research Letter

Chronic HIV-1 infection is associated with lower frequencies and functional impairment of mucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1-infected individuals on antiretroviral therapy. IL-7 led to increased relative and absolute levels of MAIT cells, and this expansion occurred primarily in the CD8+ subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.

aClinical Research Directorate/Clinical Monitoring Leidos Research Program, Leidos Biomedical Research, Inc, NCI Campus at Frederick, Frederick

bNational Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health, Bethesda, Maryland, USA

cDepartment of Medicine, Center for Infectious Medicine, Karolinska Insitutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

dProgram in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.

*Johan K. Sandberg, Irini Sereti, Ornella Sortino, and Elizabeth Richards contributed equally to the article.

Correspondence to Irini Sereti, HIV Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. E-mail: isereti@niaid.nih.gov

Received 12 October, 2017

Revised 11 December, 2017

Accepted 18 December, 2017

Copyright © 2018 Wolters Kluwer Health, Inc.