Chronic HIV-1 infection is associated with lower frequencies and functional impairment of mucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1 infected individuals on ART. IL-7 led to increased relative and absolute levels of MAIT cells and this expansion occurred primarily in the CD8+ subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.
aClinical Research Directorate / Clinical Monitoring Leidos Research Program, Leidos Biomedical Research, Inc, NCI Campus at Frederick, Maryland 21702 Provides support to
bNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
cCenter for Infectious Medicine, Department of Medicine, Karolinska Insitutet, Karolinska Univeristy Hospital Huddinge, Stockholm, Sweden
dProgram in Emerging Infectious Diseases, Duke-National Univeristy of Singapore Medical School, Singapore 169857, Singapore.
*J.K.S and I.S. contributed equally to this work.
†isereti.niaid.nih.gov (IS); email@example.com (JKS)
‡O.S. and E.R. contributed equally to this work.
Correspondence to Irini Sereti, HIV Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. E-mail: firstname.lastname@example.org
Received 12 October, 2017
Revised 11 December, 2017
Accepted 18 December, 2017