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IL-7 treatment supports CD8+ MAIT cell restoration in HIV-1 infected patients on ART

Sortino, Ornellaa,‡; Richards, Elizabethb,‡; Dias, Joanac; Leeansyah, Edwinc,d; Sandberg, Johan K.c,*,†; Sereti, Irinib,*,†

doi: 10.1097/QAD.0000000000001760
Research Letter: PDF Only

Chronic HIV-1 infection is associated with lower frequencies and functional impairment of mucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1 infected individuals on ART. IL-7 led to increased relative and absolute levels of MAIT cells and this expansion occurred primarily in the CD8+ subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.

aClinical Research Directorate / Clinical Monitoring Leidos Research Program, Leidos Biomedical Research, Inc, NCI Campus at Frederick, Maryland 21702 Provides support to

bNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

cCenter for Infectious Medicine, Department of Medicine, Karolinska Insitutet, Karolinska Univeristy Hospital Huddinge, Stockholm, Sweden

dProgram in Emerging Infectious Diseases, Duke-National Univeristy of Singapore Medical School, Singapore 169857, Singapore.

*J.K.S and I.S. contributed equally to this work.

isereti.niaid.nih.gov (IS); johan.sandberg@ki.se (JKS)

O.S. and E.R. contributed equally to this work.

Correspondence to Irini Sereti, HIV Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. E-mail: isereti@niaid.nih.gov

Received 12 October, 2017

Revised 11 December, 2017

Accepted 18 December, 2017

Copyright © 2018 Wolters Kluwer Health, Inc.