Research Letter: PDF OnlyKidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxisNickolas, Thomas L.a; Barasch, Jonathana; Mugwanya, Kenneth K.b; Branch, Andrea D.c; Heffron, Reneeb,d; Wanga, Valentineb; Mugo, Nelly R.b,f; Ronald, Allang; Celum, Connieb,e; Donnell, Deborahb; Baeten, Jared M.b,d,e; Wyatt, Christina M.h for the Partners PrEP Study TeamAuthor Information aDepartment of Medicine, Columbia Irving University Medical Center, New York, NY, USA bDepartment of Global Health, University of Washington, Seattle, WA, USA cDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA dDepartment of Epidemiology, University of Washington, Seattle, WA, USA eDepartment of Medicine, University of Washington, Seattle, WA, USA fKenya Medical Research Institute, Nairobi, Kenya gDepartments of Medicine and Medical Microbiology, University of Manitoba, Manitoba, Canada hDepartment of Medical Center, Duke University School of Medicine and Duke Clinical Research Institute, Durham NC, USA. Correspondence to Christina M. Wyatt, MD, Department of Medicine, Division of Nephrology, Duke University School of Medicine, Duke Clinical Research Institute, 200 Morris Street, Durham, NC 27705; USA. e-mail: [email protected] Received 7 August, 2020 Revised 24 September, 2020 Accepted 4 October, 2020 AIDS: March 11, 2021 - Volume Publish Ahead of Print - Issue - doi: 10.1097/QAD.0000000000002865 Buy PAP Metrics Abstract We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate among HIV-negative adults randomized to emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case-control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between subjects who subsequently experienced one of these kidney endpoints and randomly selected controls who did not. Copyright © 2021 Wolters Kluwer Health, Inc.