Research LetterEffects of early human immunodeficiency virus infection on cerebral white matter blood flow autoregulationSen, Souvika; An, Hongyub; Oakes, Jonathanc; Eron, Josephc; Robertson, Kevinc; Powers, Williamc,d Author Information aUniversity of South Carolina, Columbia, SC bWashington University, Saint Louis, MO cUniversity of North Carolina, Chapel Hill dDuke University, Durham, NC, USA. Correspondence to William Powers, MD, Department of Neurology, Duke University School of Medicine, Duke South, Room 0120A, DUMC Box 3824, Durham, NC 27710, USA. Tel: +1 919 684 5871; e-mail: [email protected] Received 6 June, 2022 Revised 22 August, 2022 Accepted 24 August, 2022 AIDS 37(2):p 359-361, February 1, 2023. | DOI: 10.1097/QAD.0000000000003378 Buy Metrics Abstract Blood flow autoregulation in cerebral white matter was measured before and after acute nicardipine-induced changes in mean arterial pressure of 10–21% in 21 treatment naïve HIV-positive adults and 32 controls. The autoregulatory index (−% cerebral blood flow change/% mean arterial pressure change) was not different at baseline (P = 0.71) or after 1 year of treatment (n = 11, P = 0.17). We found no autoregulatory defect to explain the increased stroke risk or the development of cerebral white damage in people with HIV. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.