CLINICAL SCIENCESex differences in type 2 diabetes mellitus prevalence among persons with HIVBirabaharan, Morgana; Strunk, Andrewb; Kaelber, David C.c,d; Smith, Davey M.a,e,∗; Martin, Thomas C.S.a,e,∗ Author Information aDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, California bDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York cDepartments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University dCenter for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, Ohio eSan Diego Veterans Affairs Healthcare System, San Diego, California, USA. Correspondence to Morgan Birabaharan, MD, Division of Infectious Diseases and Global Public Health, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. E-mail: [email protected] Received 21 August, 2021 Revised 6 October, 2021 Accepted 14 October, 2021 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com). AIDS: March 1, 2022 - Volume 36 - Issue 3 - p 383-389 doi: 10.1097/QAD.0000000000003127 Buy SDC Metrics Abstract Objective: To examine whether type 2 diabetes mellitus (T2DM) is more common among women with HIV (WWH) than men with HIV (MWH). Design: A cross-sectional analysis of a demographically heterogenous population-based sample of more than 64 million patients in the United States. Methods: Using the Explorys (IBM) database, compare the prevalence of T2DM among men and women without HIV and influence of HIV on T2DM by sex controlling for confounding factors. Results: From 19 182 775 persons included in the study, 39 485 were with HIV. Rates of obesity was higher among WWH than MWH (58 vs. 35%). Prevalence of T2DM among WWH was 23% compared with 16% among MWH (P < 0.001). In sex-stratified adjusted analysis, WWH had 1.31 [95% confidence interval (CI), 1.24–1.38] times the odds of having T2DM than women without HIV. Women with HIV was associated with T2DM across all demographic subgroups. In contrast, no association between HIV and T2DM was observed among men (OR 1.01; 95% CI 0.98–1.05). Conclusion: These data suggest that HIV confers a sex-specific increase in odds of T2DM among women but not men. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.