ViewpointPerforming rapid autopsy for the interrogation of HIV reservoirsRawlings, Stephen A.a,*; Layman, Lauraa,*; Smith, Daveya,b; Scott, Briannaa; Ignacio, Carolinea; Porrachia, Magalib; Concha-Garcia, Susannaa; Hendrickx, Stevena; Kaytes, Andyc; Taylor, Jeffc,d; Gianella, Saraa,bAuthor Information aDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building bVeterans Affairs Viral Research Laboratory cAntiviral Research Center Community Advisory Board, University of California, San Diego, San Diego dHIV and Aging Research Project – Palm Springs (HARP-PS), Palm Springs, California, USA. Correspondence to Sara Gianella, MD, Assistant Professor of Medicine, Center for AIDS Research, UCSD, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA. E-mail: email@example.com Received 17 January, 2020 Revised 14 March, 2020 Accepted 24 March, 2020 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com). AIDS: June 1, 2020 - Volume 34 - Issue 7 - p 1089-1092 doi: 10.1097/QAD.0000000000002546 Buy SDC Metrics Abstract Rapid autopsy at the end of life in people with HIV (PWH) permits the preservation of valuable tissue specimens for subsequent study of HIV reservoirs. At our institution, we have developed a cohort of PWH who consent to a rapid autopsy to gather a wide range of fluids and tissues with the goal of advancing HIV cure research. The protocol for successfully performing these autopsies has required careful thought and development over months and years. We have now successfully performed six rapid autopsies and detail here our steps to build the study cohort, train and staff a team of more than a dozen personnel, and process and preserve hundreds of samples from each autopsy. Copyright © 2020 Wolters Kluwer Health, Inc.