Reports of resistance to integrase strand transfer inhibitors (INSTIs) are now not uncommon. We analyzed the HIV int gene from plasma of antiretroviral-naïve individuals during acute and chronic HIV-1 infection. No individual with major INSTI mutations was identified. Two individuals harbored INSTI accessory mutations E157Q/T97A were detected for the first time. Our results emphasize the need to consider testing for INSTI resistance at baseline as this class of drugs is increasingly used in clinical routine.
aCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University
bBeijing Key Laboratory for HIV/AIDS Research
cNational AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
*Lifeng Liu and Lili Dai contributed equally to the article.
Correspondence to Bin Su, PhD, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China. Tel: +86 10 83997162; fax: +86 10 83997354; e-mail: firstname.lastname@example.org
Received 22 February, 2019
Revised 15 May, 2019
Accepted 28 May, 2019