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Lack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-naïve individuals in a tertiary care hospital in Beijing, China

Liu, Lifenga,b,*; Dai, Lilia,*; Yao, Junc; Pan, Pinliangc; Li, Lia,b; Liu, Zhiyinga,b; An, Xizhaoa,b; Sun, Lijuna; Wu, Haoa,b; Su, Bina,b; Zhang, Tonga,b

doi: 10.1097/QAD.0000000000002282
Research Letter
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Reports of resistance to integrase strand transfer inhibitors (INSTIs) are now not uncommon. We analyzed the HIV int gene from plasma of antiretroviral-naïve individuals during acute and chronic HIV-1 infection. No individual with major INSTI mutations was identified. Two individuals harbored INSTI accessory mutations E157Q/T97A were detected for the first time. Our results emphasize the need to consider testing for INSTI resistance at baseline as this class of drugs is increasingly used in clinical routine.

aCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University

bBeijing Key Laboratory for HIV/AIDS Research

cNational AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

*Lifeng Liu and Lili Dai contributed equally to the article.

Correspondence to Bin Su, PhD, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory for HIV/AIDS Research, Beijing 100069, China. Tel: +86 10 83997162; fax: +86 10 83997354; e-mail: binsu.paris7@hotmail.com

Received 22 February, 2019

Revised 15 May, 2019

Accepted 28 May, 2019

Copyright © 2019 Wolters Kluwer Health, Inc.