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GCH1 haplotypes and cardiovascular risk in HIV

Slaven, James E.a; Haas, David W.b; Liu, Ziyuea; Stein, James H.c; Brown, Todd T.d; Gupta, Samir K.e

doi: 10.1097/QAD.0000000000002263
Research Letter

Heightened systemic inflammation contributes to cardiovascular (CVD) events in people living with HIV (PLWH), although not all PLWH develop CVD, thus suggesting a genetic modifying role. We examined GCH1 polymorphisms, which have been associated with reduced endothelial function in European populations with CVD and increased inflammation, in a racially diverse cohort of US PLWH initiating antiretroviral therapy (ART). GCH1 polymorphisms differed by race and were not associated with flow-mediated dilation or carotid intima–media thickness before or after 48 weeks of ART.

aDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana

bDepartment of Medicine, Vanderbilt University, Nashville, Tennessee

cDepartment of Medicine, University of Wisconsin, Madison, Wisconsin

dDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland

eDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Correspondence to Dr Samir K. Gupta, Division of Infectious Diseases, Indiana University School of Medicine, Emerson Hall, Suite 421, 545 Barnhill Drive, Indianapolis, IN 46202, USA. Tel: +1 317 274 7926; fax: +1 317 274 1587; e-mail:

Received 17 March, 2019

Revised 29 April, 2019

Accepted 29 April, 2019

Copyright © 2019 Wolters Kluwer Health, Inc.