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Soluble suppression of tumorigenicity 2 levels are not predictive of non-AIDS events during antiretroviral therapy-mediated viral suppression

Kay, Alexisa; Moser, Carleeb; McKhann, Ashleyb; Vargas, Milenkaa; Porrachia, Magalia; Gianella, Saraa; Hoenigl, Martina

doi: 10.1097/QAD.0000000000002228
Research Letters

Before initiation of antiretroviral therapy (ART), levels of soluble suppression of tumorigenicity 2 (sST2) were not elevated in people living with HIV who later developed non-AIDS events (including myocardial infarction and stroke), compared with controls. However, higher sST2 levels measured pre-ART were a significant predictor of death while on ART. Future studies should explore the potential of sST2 to serve as a short-term predictor of non-AIDS events during viral suppression.

aDivision of Infectious Diseases, Department of Medicine, University of California San Diego, San Diego, California

bHarvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Correspondence to Sara Gianella, MD, Division of Infectious Diseases, Department of Medicine, University of California, San Diego, 200 West Arbor Drive #8208, San Diego, CA 92103, USA. Tel: +1 858642 1620; e-mail:

Received 26 January, 2019

Revised 19 February, 2019

Accepted 19 February, 2019

Copyright © 2019 Wolters Kluwer Health, Inc.