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We need to consider collateral damage to resistomes when we decide how frequently to screen for chlamydia/gonorrhoea in preexposure prophylaxis cohorts

Kenyon, Chris

doi: 10.1097/QAD.0000000000002020
Research Letter

Numerous preexposure prophylaxis (PrEP) guidelines recommend three-monthly screening for gonorrhoea and chlamydia. To quantify the risk of antimicrobial resistance this may induce, we conducted a literature review of the incidence of gonorrhoea and chlamydia in PrEP studies that conducted 3-site, 3-monthly screening. We found that screening could result in macrolide consumption rates that exceed those in high macrolide consumption populations where consumption has been strongly associated with macrolide resistance.

HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium, Division of Infectious Diseases and HIV Medicine, University of Cape Town, South Africa.

Correspondence to Chris Kenyon, Professor in Sexually Transmitted Infections, HIV/STI Unit, Institute of Tropical Medicine, Antwerp, Belgium, Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South Africa. E-mail: ckenyon@itg.be

Received 4 July, 2018

Accepted 24 July, 2018

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