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mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion

implications for HIV-1 persistence and cure research

Taylor, Harry E.; Calantone, Nina A.; D’Aquila, Richard T.

doi: 10.1097/QAD.0000000000001997
Research Letter

Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance.

Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.

Correspondence to Harry E. Taylor, Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. E-mail: harry.taylor@northwestern.edu

Received 17 July, 2018

Accepted 29 August, 2018

Copyright © 2018 Wolters Kluwer Health, Inc.