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HIV, HPV, and microbiota: partners in crime?

Serrano-Villar, Sergio; Vásquez-Domínguez, Emilia; Pérez-Molina, José Antonio; Sainz, Talía; de Benito, Amparo; Latorre, Amparo; Moya, Andrés; Gosalbes, María José; Moreno, Santiago

doi: 10.1097/QAD.0000000000001352
Research Letter

Altered interplay between gut mucosa and dysbiotic bacteria during HIV infection seems to fuel chronic immune dysfunction and might explain the excess rates of human papillomavirus (HPV)-associated anal cancer in HIV-infected individuals. Here, we show in HIV-infected MSM undergoing screening for HPV-related cancer that specific fecal and mucosal bacteria are able to predict the existence of precancerous anal lesions. If confirmed, these bacterial biomarkers could be exploited either as diagnostic tools or therapeutic targets.

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aDepartment of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá (IRYCIS), Madrid

bUnidad Mixta de Investigación en Genómica y Salud de la Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO-Salud Pública) y el Instituto Cavanilles de Biodiversidad y Biología Evolutiva (Universidad de Valencia), Valencia

cDepartment of Pediatric Infectious Diseases, Hospital Universitario La Paz (IdiPAZ)

dDepartment of Pathology, Hospital Universitario Ramón y Cajal

eCIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

*Santiago Moreno and María José Gosalbes contributed equally to this study.

Correspondence to Sergio Serrano-Villar, MD, PhD, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá (IRYCIS), Madrid, Spain. E-mail:

Received 15 September, 2016

Revised 8 November, 2016

Accepted 14 November, 2016

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