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Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

Vinuesa, Davida; Parra-Ruiz, Jorgea; Chueca, Nataliab; Alvarez, Martab; Muñoz-Medina, Leopoldoa; Garcia, Federicob; Hernandez-Quero, Josea

doi: 10.1097/QAD.0000000000000312
Research Letters

There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsil's lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P = 0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.

aService of Infectious Diseases

bService of Microbiology, Hospital Universitario San Cecilio, Granada, Spain.

Correspondence to Jorge Parra-Ruiz, MD, PhD, Servicio de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Avda. Dr Olóriz 16, 18012 Granada, Spain. Tel: +34 958 023 104; fax: +34 958 249 079; e-mail:

Received 23 February, 2014

Revised 15 April, 2014

Accepted 16 April, 2014

© 2014 Lippincott Williams & Wilkins, Inc.