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WHO guidelines for antiretroviral therapy in serodiscordant couples in sub-Saharan Africa: how many fit?

Kouamé, Gérarda; Danel, Christinea,b; Moh, Raoula,b,c; Badjé, Anania,b; Jean, Kevind; N’takpe, Jean-Baptistea,b; Gabillard, Delphinea,b; Le Carrou, Jéromea,b; du LoÛ, Annabel Desgréese; Deschamps, Ninaa; Eholie, Sergea,c; Anglaret, Xaviera,b

doi: 10.1097/QAD.0000000000000296
Research Letter

To evaluate the implication of WHO guidelines for serodiscordant couples, we interviewed HIV-infected adults on their partner's serostatus. We found that 12% with more than 500 CD4+ cells/μl should be recommended antiretroviral treatment (ART) because their partner was seronegative; 24% could be recommended not to start ART because their partner was seropositive; and 64% could not be given any recommendation regarding ART early initiation because they had either no stable partnership (30%) or were in a stable partnership with a partner whose status they were not aware of (34%).

aPAC-CI, ANRS Research Site, Abidjan, Côte d’Ivoire

bInserm, U897, University of Bordeaux, Bordeaux, France

cInfectious Diseases Department, Treichville University Hospital, Abidjan, Côte d’Ivoire

dInserm, UMRS 1018, Université Versailles Saint-Quentin, Villejuif

eCEPED (Centre de Population et Développement), UMR 196, Ined, IRD, Université Paris Descartes, Paris, France.

Correspondence to Xavier Anglaret, Programme PACCI, 18 BP 1954, Abidjan 18, Côte d’Ivoire. Tel: +225 21755960; e-mail:

Received 7 March, 2014

Revised 28 March, 2014

Accepted 31 March, 2014

© 2014 Lippincott Williams & Wilkins, Inc.