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Protective effect of hepatitis B virus-active antiretroviral therapy against primary hepatitis B virus infection

Heuft, Merel M.a; Houba, Sanne M.a; van den Berk, Guido E.L.a; Smissaert van de Haere, Tessaa; van Dam, Alje P.b; Dijksman, Lea M.c; Regez, Rosa M.a; Brinkman, Keesa

doi: 10.1097/QAD.0000000000000180
Clinical Science

Objective: Current guidelines advise to vaccinate every hepatitis B virus (HBV)-susceptible HIV patient against HBV until sufficient antibody titers have been reached. However, in this era of combination antiretroviral therapy (cART), acute HBV infection rarely occurs in patients who lack this immune protection. We analyzed whether HBV-active cART (lamivudine, emtricitabine, tenofovir) might work as a preexposure prophylaxis (PrEP) to explain this effect.

Methods: From our HIV cohort at the Onze Lieve Vrouwe Gasthuis hospital (N = 2942), patients were selected retrospectively for negative HBV serology (HBsAg, anti-HBs and anti-HBc-negative) at cohort entry. Men who have sex with men (MSM) with a second HBV serology available were included for analysis. The incidence of anti-HBc conversion was determined and correlated with the use of HBV-active drugs. Kaplan–Meier curves and log-rank tests were used to compare HBV-free survival for MSM.

Results: In total, 33 HBV infections occurred in 381 eligible MSM over a median follow-up of 2470 days (interquartile range 1146–3871.5). The incident rate per 100 patient-years of follow-up was 1.10 overall, but differed strongly dependent on the use of HBV-active drugs: 2.85/100 patient-years of follow-up in the absence of HBV-active drugs, 1.36 when only lamivudine was used, and 0.14 in the presence of tenofovir. Furthermore, HBV-free survival rate was significantly higher when HBV-active cART was used, in particular when this HBV-active cART contained tenofovir (log-rank P <0.001).

Conclusion: Our findings demonstrate that HBV-active cART protects against the occurrence of de-novo HBV infection, most strongly when tenofovir is used.

aDepartment of Internal Medicine

bDepartment of Medical Microbiology

cTeaching Hospital, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.

Correspondence to Kees Brinkman, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC Amsterdam, The Netherlands. E-mail:

Received 30 June, 2013

Revised 9 December, 2013

Accepted 9 December, 2013

This study was presented as oral paper at the Conference of Retroviruses and Opportunistic Infections 2013, Atlanta.

© 2014 Lippincott Williams & Wilkins, Inc.