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Decreasing cardiovascular risk in HIV infection between 2005 and 2011

De Socio, Giuseppe V.a; Parruti, Giustinob; Ricci, Elenac; Maggi, Paolod; Celesia, Benedetto M.e; Penco, Giovannif; Martinelli, Caniog; Franzetti, Marcoh; Di Biagio, Antonioi; Bonfanti, Paoloj; Pucci, Giacomok; Schillaci, Giuseppekfor the CISAI study group

doi: 10.1097/QAD.0000000000000181
Research Letters

Cardiovascular risk profile was compared in 765 Italian HIV-infected outpatients enrolled in 2005 and in 765 individually age-matched and sex-matched patients enrolled in 2011. Median Framingham risk score was 8.6% in 2005 vs. 7.9% in 2011 (P = 0.04); metabolic syndrome was present in 40.3% vs. 33.4% (P = 0.006). Blood glucose, triglycerides, prevalence of smokers, and lipodystrophy were all significantly lower in 2011 (all P <0.0001). Cardiovascular risk improved over a 6-year period in Italian HIV-infected patients.

aDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria di Perugia, Perugia

bDepartment of Infectious Diseases, Pescara Hospital, Pescara

cDepartment of Infectious Diseases, Luigi Sacco Hospital, Milan

dDepartment of Infectious Diseases, University of Bari, Bari

eDepartment of Infectious Diseases, Garibaldi Hospital, University of Catania, Catania

fDepartment of Infectious Diseases, Galliera Hospital, Genoa, Genoa

gDepartment of Infectious Diseases, Careggi Hospital, Florence

hDepartment of Infectious Diseases, University of Milan, Milan

iDepartment of Infectious Diseases, San Martino Hospital Genoa, University of Genoa, Genoa

jDepartment of Infectious Diseases, Manzoni Hospital, Lecco

kUniversità di Perugia and Struttura Complessa di Medicina Interna, Azienda Ospedaliero-Universitaria di Terni, Terni, Italy.

Correspondence to Giuseppe V.L. De Socio, MD, PhD, Clinica di Malattie Infettive, Azienda Ospedaliero-Universitaria di Perugia, Piazzale Menghini 1, 06129 Perugia, Italy. Tel: +39 075 5784321; fax: +39 075 5784346; e-mail:

Received 18 September, 2013

Revised 9 December, 2013

Accepted 9 December, 2013

Copyright © 2014 Wolters Kluwer Health, Inc.