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Evidence for continuing cross-species transmission of SIVsmm to humans: characterization of a new HIV-2 lineage in rural Côte d’Ivoire

Ayouba, Ahidjoa; Akoua-Koffi, Chantalb; Calvignac-Spencer, Sébastienc; Esteban, Amandinea; Locatelli, Sabrinaa; Li, Huid; Li, Yingyingd; Hahn, Beatrice H.d; Delaporte, Erica; Leendertz, Fabian H.c; Peeters, Martinea

doi: 10.1097/01.aids.0000432443.22684.50
Research Letters

HIV types 1 and 2 (HIV-1 and HIV-2) are the result of multiple cross-species transmissions of their simian counterparts (SIVs) to humans. We studied whether new SIVs lineages have been transmitted to humans in rural Côte d’Ivoire and identified a novel HIV-2 variant (HIV-2-07IC-TNP03) not related to any of the previously defined HIV-2 groups. This finding shows that sooty mangabey viruses continue to be transmitted to humans, causing new zoonotic outbreaks.

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aUMI 233, IRD and University of Montpellier 1, Montpellier, France

bDepartment of Diagnostics, Teaching Hospital, University of Bouake, Côte d’Ivoire

cProject group Epidemiology of Highly Pathogenic Microorganisms RKI, Berlin, Germany

dDepartment of Microbiology and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Correspondence to Dr Ahidjo Ayouba, PhD, IRD/University Montpellier 1, Montpellier, France. E-mail:

Preliminary results of this work have been presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, Washington, USA, (5–8 March, 2012), Abstract No. 62LB.

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© 2013 Lippincott Williams & Wilkins, Inc.